José Jerovane da Costa Nascimento , Adriell Gomes Marques , Lucas do Nascimento Souza , Carlos Mauricio Jaborandy de Mattos Dourado Junior , Antonio Carlos da Silva Barros , Victor Hugo C. de Albuquerque , Luís Fabrício de Freitas Sousa
{"title":"A novel generative model for brain tumor detection using magnetic resonance imaging","authors":"José Jerovane da Costa Nascimento , Adriell Gomes Marques , Lucas do Nascimento Souza , Carlos Mauricio Jaborandy de Mattos Dourado Junior , Antonio Carlos da Silva Barros , Victor Hugo C. de Albuquerque , Luís Fabrício de Freitas Sousa","doi":"10.1016/j.compmedimag.2025.102498","DOIUrl":null,"url":null,"abstract":"<div><div>Brain tumors are a disease that kills thousands of people worldwide each year. Early identification through diagnosis is essential for monitoring and treating patients. The proposed study brings a new method through intelligent computational cells that are capable of segmenting the tumor region with high precision. The method uses deep learning to detect brain tumors with the “You only look once” (Yolov8) framework, and a fine-tuning process at the end of the network layer using intelligent computational cells capable of traversing the detected region, segmenting the edges of the brain tumor. In addition, the method uses a classification pipeline that combines a set of classifiers and extractors combined with grid search, to find the best combination and the best parameters for the dataset. The method obtained satisfactory results above 98% accuracy for region detection, and above 99% for brain tumor segmentation and accuracies above 98% for binary classification of brain tumor, and segmentation time obtaining less than 1 s, surpassing the state of the art compared to the same database, demonstrating the effectiveness of the proposed method. The new approach proposes the classification of different databases through data fusion to classify the presence of tumor in MRI images, as well as the patient’s life span. The segmentation and classification steps are validated by comparing them with the literature, with comparisons between works that used the same dataset. The method addresses a new generative AI for brain tumor capable of generating a pre-diagnosis through input data through Large Language Model (LLM), and can be used in systems to aid medical imaging diagnosis. As a contribution, this study employs new detection models combined with innovative methods based on digital image processing to improve segmentation metrics, as well as the use of Data Fusion, combining two tumor datasets to enhance classification performance. The study also utilizes LLM models to refine the pre-diagnosis obtained post-classification. Thus, this study proposes a Computer-Aided Diagnosis (CAD) method through AI with PDI, CNN, and LLM.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"121 ","pages":"Article 102498"},"PeriodicalIF":4.9000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computerized Medical Imaging and Graphics","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0895611125000072","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Brain tumors are a disease that kills thousands of people worldwide each year. Early identification through diagnosis is essential for monitoring and treating patients. The proposed study brings a new method through intelligent computational cells that are capable of segmenting the tumor region with high precision. The method uses deep learning to detect brain tumors with the “You only look once” (Yolov8) framework, and a fine-tuning process at the end of the network layer using intelligent computational cells capable of traversing the detected region, segmenting the edges of the brain tumor. In addition, the method uses a classification pipeline that combines a set of classifiers and extractors combined with grid search, to find the best combination and the best parameters for the dataset. The method obtained satisfactory results above 98% accuracy for region detection, and above 99% for brain tumor segmentation and accuracies above 98% for binary classification of brain tumor, and segmentation time obtaining less than 1 s, surpassing the state of the art compared to the same database, demonstrating the effectiveness of the proposed method. The new approach proposes the classification of different databases through data fusion to classify the presence of tumor in MRI images, as well as the patient’s life span. The segmentation and classification steps are validated by comparing them with the literature, with comparisons between works that used the same dataset. The method addresses a new generative AI for brain tumor capable of generating a pre-diagnosis through input data through Large Language Model (LLM), and can be used in systems to aid medical imaging diagnosis. As a contribution, this study employs new detection models combined with innovative methods based on digital image processing to improve segmentation metrics, as well as the use of Data Fusion, combining two tumor datasets to enhance classification performance. The study also utilizes LLM models to refine the pre-diagnosis obtained post-classification. Thus, this study proposes a Computer-Aided Diagnosis (CAD) method through AI with PDI, CNN, and LLM.
期刊介绍:
The purpose of the journal Computerized Medical Imaging and Graphics is to act as a source for the exchange of research results concerning algorithmic advances, development, and application of digital imaging in disease detection, diagnosis, intervention, prevention, precision medicine, and population health. Included in the journal will be articles on novel computerized imaging or visualization techniques, including artificial intelligence and machine learning, augmented reality for surgical planning and guidance, big biomedical data visualization, computer-aided diagnosis, computerized-robotic surgery, image-guided therapy, imaging scanning and reconstruction, mobile and tele-imaging, radiomics, and imaging integration and modeling with other information relevant to digital health. The types of biomedical imaging include: magnetic resonance, computed tomography, ultrasound, nuclear medicine, X-ray, microwave, optical and multi-photon microscopy, video and sensory imaging, and the convergence of biomedical images with other non-imaging datasets.