Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress

IF 4.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic Chemistry Pub Date : 2025-02-19 DOI:10.1016/j.bioorg.2025.108277

Si-Yi Wang , Meng-Meng Li , Ye Sun , Jia-Tong Wu , Wei Guan , Yi-Kai Jiang , Hong-Yan Yao , Xiao-Xue He , Jiu-jiang Yan , Qing-shan Chen , Li-Li Zhang , Anam Naseem , Xiao-Chi Ma , Hai-Xue Kuang , Bing-You Yang , Yan Liu

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Abstract

Schisandra chinensis (Turcz.) Baill, which is frequently used in health products and drinks, is recognized for its high content of essential oils that could have protective effects against PD, despite the lack of complete understanding of its pharmacological mechanisms. This research aims to examine how ESC can affect autophagy signaling pathways and activate the Nrf2/HO-1 pathway to effectively decrease oxidative damage, thus shedding light on the possible anti-PD effects of this treatment. The results demonstrated that ESC significantly reduced behavioral issues linked to Parkinson's disease in a mouse model that was induced by MPTP and safeguarded dopaminergic neurons that expressed tyrosine hydroxylase. Moreover, ESC boosted the antioxidant capability of Nrf2, assisted with autophagy processes, and finally decreased protein expression levels of Keap1, HO-1, MAPK, mTOR, and ERK. According to in vitro studies, ESC treatment had a significant reduction in H₂O₂-induced cytotoxicity and oxidative stress levels, which suggests that Nrf2 targets ESC after treatment. The activation of both autophagy and Nrf2 antioxidant pathways was assessed using western blotting. In conclusion, ESC exhibits the potential to suppress oxidative stress by activating Nrf2 in response to autophagy, which is positioned as a promising pharmaceutical candidate, especially for the management and treatment of PD and related disorders.

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五味子挥发油（Turcz.）Baill通过激活Nrf2通路正向调节自噬和氧化应激，缓解帕金森病

五味子（土耳其）白藜芦醇经常用于保健产品和饮料中，尽管对其药理机制缺乏完整的了解，但它因其高含量的精油可能对PD有保护作用而得到认可。本研究旨在探讨ESC如何影响自噬信号通路，激活Nrf2/HO-1通路，从而有效减少氧化损伤，从而揭示ESC治疗可能的抗pd作用。结果表明，在MPTP诱导的小鼠模型中，ESC显著减少了与帕金森病相关的行为问题，并保护了表达酪氨酸羟化酶的多巴胺能神经元。此外，ESC可以增强Nrf2的抗氧化能力，辅助自噬过程，最终降低Keap1、HO-1、MAPK、mTOR和ERK的蛋白表达水平。根据体外研究，ESC处理显著降低h2o2诱导的细胞毒性和氧化应激水平，这表明Nrf2在处理后靶向ESC。western blotting检测自噬和Nrf2抗氧化途径的激活情况。综上所述，ESC在自噬反应中通过激活Nrf2来抑制氧化应激，这是一种有前景的候选药物，特别是在PD和相关疾病的管理和治疗中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioorganic Chemistry 生物-生化与分子生物学

CiteScore

9.70

自引率

3.90%

发文量

679

审稿时长

31 days

期刊介绍： Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry. For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature. The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.