Yang Li, Yan-Ping Lu, Xin-Han Yang, Tian-Ci Jie, Peng Shen, Chunyu Xia* and Guang-Yao Ran*,
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引用次数: 0
Abstract
Compared with previously electrophilic benzofulvenes with exclusive reaction regioselectivity of the exocyclic double bond, novel lactone-embedded benzofulvenes with nucleophilicity and unique chemical properties have been designed and utilized in palladium-catalyzed sequential assembly with π-allylic species and various nucleophiles (including methoxide anion, alcohols, anilines, and alkylamines) through an unprecedented tandem allylation/ester bond cleavage process probably via a key oxocarbenium ion. The protocol featured high chemoselectivity and regioselectivity, constructing an array of densely functionalized indenes in high yields. Furthermore, the biological evaluation revealed that the synthesized indenes exhibited antitumor activity.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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