tRNA intron-derived small regulatory RNAs fine-tune gene expression under oxidative stress

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-02-20 DOI:10.1016/j.molcel.2025.01.026

Duo Pan, Mo-Fang Liu

引用次数: 0

Abstract

The intron sequences of certain tRNAs are evolutionarily conserved among specific organisms, implying potential cellular functions of such tRNA introns. In this issue, Nostramo et al.¹ identify free introns of tRNAs (fitRNAs) in S. cerevisiae as small regulatory RNAs that dynamically control mRNA levels in response to oxidative stress.

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某些 tRNA 的内含子序列在特定生物之间具有进化保守性，这意味着这些 tRNA 内含子具有潜在的细胞功能。在本期杂志中，Nostramo 等人1 发现 S. cerevisiae 中的 tRNAs 自由内含子（fitRNAs）是一种小型调控 RNAs，可在氧化应激时动态控制 mRNA 水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.