Outcomes of procedures for abortions and early pregnancy loss among people with sickle cell disease: A single-center experience

IF 2.5 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of the National Medical Association Pub Date : 2025-02-01 DOI:10.1016/j.jnma.2025.01.003

Sydney A. Wade , Erin Y. Chen , Preetha Nandi , Sophie M. Lanzkron , Anne E. Burke , Lydia H. Pecker

{"title":"Outcomes of procedures for abortions and early pregnancy loss among people with sickle cell disease: A single-center experience","authors":"Sydney A. Wade , Erin Y. Chen , Preetha Nandi , Sophie M. Lanzkron , Anne E. Burke , Lydia H. Pecker","doi":"10.1016/j.jnma.2025.01.003","DOIUrl":null,"url":null,"abstract":"<div><div>People with sickle cell disease (SCD) have an increased risk of pregnancy loss and severe maternal morbidity in pregnancy yet there is little data on the outcomes of abortions or pregnancy loss among these individuals. This retrospective review aimed to describe the clinical outcomes of procedurally managed abortions and early pregnancy losses among individuals with sickle cell disease at a single center. We identified 19 individuals with sickle cell disease who underwent 24 procedures for the management of abortion (<em>n</em> = 18) or pregnancy loss (<em>n</em> = 6) at our center from 2013 to 2022. There were few procedure-related complications. Most of the post-procedural complications were painful crises. Individuals with a high frequency of painful crises before the procedure had a 1.2 higher odds of experiencing post-procedural painful crises (95 % CI: 1.0–1.4). Individuals with higher baseline rates of painful crises were more likely to develop post-procedural pain crises. This study is the first since 1995 to report on abortion and pregnancy loss outcomes in SCD. As threats to accessing reproductive health care continue to grow in the U.S., we must refine practice models to deliver safe care to patients with SCD who seek reproductive health services.</div></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"117 1","pages":"Pages 25-31"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the National Medical Association","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0027968425000082","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

People with sickle cell disease (SCD) have an increased risk of pregnancy loss and severe maternal morbidity in pregnancy yet there is little data on the outcomes of abortions or pregnancy loss among these individuals. This retrospective review aimed to describe the clinical outcomes of procedurally managed abortions and early pregnancy losses among individuals with sickle cell disease at a single center. We identified 19 individuals with sickle cell disease who underwent 24 procedures for the management of abortion (n = 18) or pregnancy loss (n = 6) at our center from 2013 to 2022. There were few procedure-related complications. Most of the post-procedural complications were painful crises. Individuals with a high frequency of painful crises before the procedure had a 1.2 higher odds of experiencing post-procedural painful crises (95 % CI: 1.0–1.4). Individuals with higher baseline rates of painful crises were more likely to develop post-procedural pain crises. This study is the first since 1995 to report on abortion and pregnancy loss outcomes in SCD. As threats to accessing reproductive health care continue to grow in the U.S., we must refine practice models to deliver safe care to patients with SCD who seek reproductive health services.

查看原文本刊更多论文

镰状细胞病患者流产和早期妊娠流产的结果：单中心研究

患有镰状细胞病（SCD）的人在怀孕期间流产和严重孕产妇发病率的风险增加，但关于这些人流产或流产的结果的数据很少。本回顾性综述旨在描述单个中心镰状细胞病患者的手术流产和早期妊娠丢失的临床结果。我们确定了19例镰状细胞病患者，他们在2013年至2022年期间在我们的中心接受了24次流产（n = 18）或流产（n = 6）的治疗。几乎没有手术相关的并发症。大多数术后并发症是痛苦的危机。术前疼痛危机频率高的个体在手术后经历疼痛危机的几率高出1.2 （95% CI: 1.0-1.4）。疼痛危机基线率较高的个体更有可能出现手术后疼痛危机。这项研究是自1995年以来首次报道SCD的流产和流产结果。由于在美国获得生殖保健的威胁持续增长，我们必须改进实践模式，为寻求生殖保健服务的SCD患者提供安全的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of the National Medical Association 医学-医学：内科

CiteScore

4.80

自引率

3.00%

发文量

139

审稿时长

98 days

期刊介绍： Journal of the National Medical Association, the official journal of the National Medical Association, is a peer-reviewed publication whose purpose is to address medical care disparities of persons of African descent. The Journal of the National Medical Association is focused on specialized clinical research activities related to the health problems of African Americans and other minority groups. Special emphasis is placed on the application of medical science to improve the healthcare of underserved populations both in the United States and abroad. The Journal has the following objectives: (1) to expand the base of original peer-reviewed literature and the quality of that research on the topic of minority health; (2) to provide greater dissemination of this research; (3) to offer appropriate and timely recognition of the significant contributions of physicians who serve these populations; and (4) to promote engagement by member and non-member physicians in the overall goals and objectives of the National Medical Association.