{"title":"Prevalence of antibodies against dengue virus in the city of Buenos Aires: Results of a probabilistic population survey.","authors":"Cristián Biscayart, Patricia Angeleri, María Belén Bouzas, Lilia Mammana, Alejandro Macchia","doi":"10.1371/journal.pntd.0012886","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Dengue is a rapidly growing global health issue. In Argentina, the disease burden is primarily based on case reports or retrospective series; however, there are no prospective probabilistic studies available. To estimate the seroprevalence of antibodies against the dengue virus (DENV) in adult residents of Buenos Aires, at the end of the 2023 season, which culminated in Argentina's largest recorded dengue outbreak, and immediately before the subsequent outbreak at the beginning of 2024.</p><p><strong>Methods: </strong>A stratified, multi-stage probabilistic population survey was conducted to ensure representativeness of the adult population of Buenos Aires, considering geographical and socio-economic diversity.The survey determined the seroprevalence rate of DENV IgG and IgM antibodies using a rapid chromatographic immunoassay. Antibody positive participants were invited for re-testing to confirm antibody result using an enzyme-linked fluorescence assay (ELFA) technique.</p><p><strong>Results: </strong>Out of a sampling frame of 2,998 selected households, the interviewers visited 100% of the residences. The overall response rate was 26.8%. A total of 804 participants were enrolled, representing the city's 2.38 million adult population. Weighted estimates showed a total of 193,707 people aged 18 and over have antibodies to DENV. This implies a weighted prevalence [95% CI] of 8.12% [8.08%-8.15%]. The prevalence varied across different areas of the city. In the slums, the overall prevalence was twice as high (14.7% [14.5%-14.9%]) compared to the rest of the city (7.67% [7.63%-7.70%]).</p><p><strong>Conclusion: </strong>Seroprevalence results in adults in Buenos Aires show a moderate DENV infection rate, although still far from the thresholds usually considered for initiating a mass vaccination campaign. These results underscore the need for frequent surveys.</p>","PeriodicalId":49000,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"19 2","pages":"e0012886"},"PeriodicalIF":3.4000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856294/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PLoS Neglected Tropical Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1371/journal.pntd.0012886","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Dengue is a rapidly growing global health issue. In Argentina, the disease burden is primarily based on case reports or retrospective series; however, there are no prospective probabilistic studies available. To estimate the seroprevalence of antibodies against the dengue virus (DENV) in adult residents of Buenos Aires, at the end of the 2023 season, which culminated in Argentina's largest recorded dengue outbreak, and immediately before the subsequent outbreak at the beginning of 2024.
Methods: A stratified, multi-stage probabilistic population survey was conducted to ensure representativeness of the adult population of Buenos Aires, considering geographical and socio-economic diversity.The survey determined the seroprevalence rate of DENV IgG and IgM antibodies using a rapid chromatographic immunoassay. Antibody positive participants were invited for re-testing to confirm antibody result using an enzyme-linked fluorescence assay (ELFA) technique.
Results: Out of a sampling frame of 2,998 selected households, the interviewers visited 100% of the residences. The overall response rate was 26.8%. A total of 804 participants were enrolled, representing the city's 2.38 million adult population. Weighted estimates showed a total of 193,707 people aged 18 and over have antibodies to DENV. This implies a weighted prevalence [95% CI] of 8.12% [8.08%-8.15%]. The prevalence varied across different areas of the city. In the slums, the overall prevalence was twice as high (14.7% [14.5%-14.9%]) compared to the rest of the city (7.67% [7.63%-7.70%]).
Conclusion: Seroprevalence results in adults in Buenos Aires show a moderate DENV infection rate, although still far from the thresholds usually considered for initiating a mass vaccination campaign. These results underscore the need for frequent surveys.
期刊介绍：
PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy.
The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability.
All aspects of these diseases are considered, including:
Pathogenesis
Clinical features
Pharmacology and treatment
Diagnosis
Epidemiology
Vector biology
Vaccinology and prevention
Demographic, ecological and social determinants
Public health and policy aspects (including cost-effectiveness analyses).
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