Impact of bladder volume and bladder shape on radiotherapy consistency and treatment interruption in prostate cancer patients

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Applied Clinical Medical Physics Pub Date : 2025-02-19 DOI:10.1002/acm2.70026

Sijuan Huang, Ting Li, Yujun Guo, Xiuying Mai, Xinyi Dai, Manli Wu, Mengxue He, Yang Liu, Liru He, Xin Yang

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引用次数: 0

Abstract

Background

To investigate the effect of bladder volume (BV) and bladder shape on consistency and treatment interruption in prostate cancer radiotherapy (RT).

Methods

A total of 275 patients who underwent radical prostate cancer RT in our institution from April 2015 to December 2022 were enrolled. Bladder height, bladder width, and bladder length were defined and recorded. The receiver operating characteristic (ROC) curves were used to evaluate the best cut-off point for bladder shape. Logistic regression analysis was used to analyze the relationship between setup errors and bladder shapes and BV.

Results

Based on the ROC curves for 275 patients, the bladder shapes were classified into three: (a) the elongated bladder, (b) the spherical bladder, and (c) the oval bladder. Sixty-six prostate cancer patients (1611 CBCTs) were randomly selected proportionally. It was found that bladder shape has a greater impact on setup errors than BV (BV: OR = 1.470, p = 0.037; bladder shape: OR = 2.013, p < 0.001), and the setup error of the spherical bladder in anterior–posterior (AP) direction was greater than the others (p < 0.001). In addition, the shape consistency of the spherical bladder was the worst (43.0%) during RT. Compared with the inconsistent group, the group with the same bladder shape had higher consistency in BV_(CBCT/CT) (p < 0.001), and a smaller setup error in the AP direction (p < 0.001). Similarly, the treatment interruption fractions were highest in spherical bladder RT.

Conclusions

More specific bladder filling requirements should be developed for different bladder shapes. More attention should be paid to the spherical bladder for precise RT.

Abstract Image

查看原文本刊更多论文

膀胱体积和膀胱形状对前列腺癌患者放疗一致性和治疗中断的影响。

背景：探讨膀胱体积（BV）和膀胱形状对前列腺癌放疗一致性和治疗中断的影响。方法：选取2015年4月至2022年12月在我院行根治性前列腺癌放疗的患者275例。定义并记录膀胱高度、膀胱宽度和膀胱长度。采用受试者工作特征（ROC）曲线评价膀胱形状的最佳分界点。采用Logistic回归分析设置误差与膀胱形状和膀胱体积的关系。结果：根据275例患者的ROC曲线，将膀胱形状分为三种：(a)细长型膀胱，(b)球形膀胱，(c)椭圆形膀胱。按比例随机选择66例前列腺癌患者（1611例cbct）。膀胱形状对设置误差的影响大于BV (BV: OR = 1.470, p = 0.037；膀胱形态：OR = 2.013, p (CBCT/CT) (p)结论：不同膀胱形态应制定更具体的膀胱填充要求。要进行精确的放射治疗，更应注意球形膀胱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Clinical Medical Physics 医学-核医学

CiteScore

3.60

自引率

19.00%

发文量

331

审稿时长

3 months

期刊介绍： Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic