Symptom reduction in advanced cancer from multi-session mindful breathing: randomised controlled study.

IF 2 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES
Yu Zhen Tung, Diana Leh Ching Ng, Natalie Zi Lai, Chui Munn Ang, Poh Khuen Lim, Sheriza Izwa Zainuddin, Chee Loong Lam, Ee Chin Loh, Chee Shee Chai, Seng Beng Tan
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引用次数: 0

Abstract

Objectives: While single-session mindful breathing shows symptom reduction in palliative care, data on multi-session efficacy is lacking. This study aimed to determine the effectiveness of multi-session mindful breathing in reducing symptoms among patients with advanced cancer.

Methods: Adult patients with advanced cancer who scored ≥4 in at least two or more symptoms based on the Edmonton Symptom Assessment Scale (ESAS) were recruited from January to March 2020 at the University of Malaya Medical Centre, Malaysia. Participants were randomly assigned to receive either four daily sessions of 30 min mindful breathing and standard care (intervention) or standard care alone (control). The outcome measured was the change in the ESAS score after each session.

Results: 80 patients were recruited and randomised equally into the intervention and control groups. The demographic and clinical characteristics between the two groups were not statistically different. For the intervention group, there were statistically significant reductions in the total ESAS scores following all four sessions of 30 min mindful breathing (n1=40: z1=-5.09, p<0.001; z2=-3.77, p<0.001; z3=-4.38, p<0.001; z4=-3.27, p<0.05). For the control group, statistically significant reductions in the total ESAS scores were seen only after sessions 1 and 3 (n2=40: z1=-4.04, p<0.001; z3=-4.53, p<0.001).

Conclusions: Our result provides evidence that four daily sessions of 30 min mindful breathing may be effective in reducing multiple symptoms rapidly in patients with advanced cancer.

Trial registration number: NCT05910541.

多期正念呼吸减少晚期癌症症状:随机对照研究。
目的:虽然单次正念呼吸在姑息治疗中显示症状减轻,但缺乏多次疗效的数据。本研究旨在确定多阶段正念呼吸在减轻晚期癌症患者症状方面的有效性。方法:根据埃德蒙顿症状评估量表(ESAS),于2020年1月至3月在马来西亚马来亚大学医学中心招募至少两项或多项症状评分≥4分的成年晚期癌症患者。参与者被随机分配接受每天4次30分钟的正念呼吸和标准护理(干预)或单独标准护理(对照组)。测量的结果是每次治疗后ESAS评分的变化。结果:80例患者被随机分为干预组和对照组。两组患者的人口学和临床特征无统计学差异。干预组在进行4次30分钟正心呼吸后,ESAS总分均有统计学显著降低(n1=40: z1=-5.09, p2=-3.77, p3=-4.38, p4=-3.27, p2=40: z1=-4.04, p3=-4.53, p)。结论:我们的结果提供了证据,证明每天4次30分钟正心呼吸可能有效地快速减轻晚期癌症患者的多种症状。试验注册号:NCT05910541。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMJ Supportive & Palliative Care
BMJ Supportive & Palliative Care Medicine-Medicine (miscellaneous)
CiteScore
4.60
自引率
7.40%
发文量
170
期刊介绍: Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance. We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication. In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.
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