Novel multiple focal point technique for laser-induced shear wave generation in deep tissue: simulation insights.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Reza Bahrami Gorji, Mohammad Mohammadi, Bahador Makkiabadi
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引用次数: 0

Abstract

Purpose. Laser applications in biomedical imaging have several decades of history; however, some unexplored corners remain for study. While previous studies contain massive data on photoacoustic imaging, optical coherence imaging/elastography, and surface acoustic waves, the generation of shear waves in bulk by laser remained rarely investigated. Here, we study the applicability of multipoint laser exposure to generate deep tissue shear waves, which have potential applications in dynamic elastography.Method. Previous studies used single shots of laser to induce shear waves and create weak waves. Based on this, we suggest a multipoint approach to enhancing the amplitude of the shear wave in bulk. These approaches contain supersonic exposure, overlay Mach 1, and comb-push exposure in a finite element simulation environment.Result. Although the results showed a linear relationship between laser power and shear wave amplitude, the supersonic and overlay exposure increased the amplitude from 15 nm to over 60 nm and 230 nm, respectively.Conclusion. Our approaches showed a potentially successful increase in shear wave amplitude in the simulation environment. However, experimental data still need to be investigated before these techniques can be suggested for laser-induced shear wave elastography in the deep medium.

激光诱导深层组织横波产生的新型多焦点技术:模拟见解。
目的:激光在生物医学成像中的应用已有几十年的历史;然而,仍有一些未被探索的角落有待研究。虽然先前的研究包含了光声成像、光学相干成像/弹性成像和表面声波的大量数据,但激光产生的剪切波仍然很少被研究。在此,我们研究了多点激光照射产生深层组织剪切波的适用性,这在动态弹性成像中具有潜在的应用前景。方法:先前的研究采用单次激光照射来诱导剪切波和产生弱波。在此基础上,我们提出了一种多点增强体块剪切波振幅的方法。结果:虽然结果显示激光功率与剪切波振幅呈线性关系,但超音速和叠加暴露分别将剪切波振幅从15 nm增加到60 nm以上和230 nm以上。结论: ;我们的方法显示了模拟环境中剪切波振幅的潜在成功增加。然而,在这些技术可以用于深部介质中激光诱导横波弹性成像之前,仍需要对实验数据进行研究。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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