Bridging the gap: Understanding Latino willingness to participate in public health and clinical trials research across diverse subgroups

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary Clinical Trials Communications Pub Date : 2025-02-03 DOI:10.1016/j.conctc.2025.101440

Mary A. Garza PhD , Yan Li PhD , Craig S. Fryer DrPH , Luciana C. Assini-Meytin PhD , Segen Ghebrendrias MSN , Christina Celis Puga MPH , James Butler lll DrPH , Sandra C. Quinn PhD , Stephen B. Thomas PhD

{"title":"Bridging the gap: Understanding Latino willingness to participate in public health and clinical trials research across diverse subgroups","authors":"Mary A. Garza PhD , Yan Li PhD , Craig S. Fryer DrPH , Luciana C. Assini-Meytin PhD , Segen Ghebrendrias MSN , Christina Celis Puga MPH , James Butler lll DrPH , Sandra C. Quinn PhD , Stephen B. Thomas PhD","doi":"10.1016/j.conctc.2025.101440","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The underrepresentation of racial and ethnic minoritized populations in public health and clinical trials research remains a persistent issue. Yet, despite the growing body of literature investigating Latino participation in research, studies examining differences <em>between</em> Latino sub-groups remains limited. The purpose of this study was to investigate how knowledge, awareness and willingness to participate in research differs between US- born and immigrant Latinos.</div></div><div><h3>Methods</h3><div>We conducted a population-based household telephone survey with Latino adults (N = 1264), with 68 % Mexican/Mexican American, 11 % Central/South American, 8 % Puerto Rican and the remaining 13 % self-identified as “Other”. The “Building Trust Survey,” included valid standardized instruments designed to assess knowledge of research, human subjects' protections, previous participation in research, immigrant status (nativity), length of time in the US, and country of origin.</div></div><div><h3>Results</h3><div>The study found that Latinos who immigrated to the US as teens or young adults were more willing to participate in medical research than those born in the US. Willingness to \"take\" something in a study varied by Latino subgroup, immigration age, gender, and age. Analysis highlighted that Mexican/Mexican Americans (76 %) and Central/South Americans (74 %) indicated a willingness to participate in research but also were less likely to have been “Asked” to participate in research (9 % and 6 % respectively) compared to the other subgroups (p < .05).</div></div><div><h3>Conclusions</h3><div>Insights from this study will inform the development of culturally tailored interventions aimed at successfully recruiting and retaining Latino populations in public health and clinical trials research, thereby contributing to more equitable and representative health outcomes.</div></div>","PeriodicalId":37937,"journal":{"name":"Contemporary Clinical Trials Communications","volume":"44 ","pages":"Article 101440"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary Clinical Trials Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451865425000146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

The underrepresentation of racial and ethnic minoritized populations in public health and clinical trials research remains a persistent issue. Yet, despite the growing body of literature investigating Latino participation in research, studies examining differences between Latino sub-groups remains limited. The purpose of this study was to investigate how knowledge, awareness and willingness to participate in research differs between US- born and immigrant Latinos.

Methods

We conducted a population-based household telephone survey with Latino adults (N = 1264), with 68 % Mexican/Mexican American, 11 % Central/South American, 8 % Puerto Rican and the remaining 13 % self-identified as “Other”. The “Building Trust Survey,” included valid standardized instruments designed to assess knowledge of research, human subjects' protections, previous participation in research, immigrant status (nativity), length of time in the US, and country of origin.

Results

The study found that Latinos who immigrated to the US as teens or young adults were more willing to participate in medical research than those born in the US. Willingness to "take" something in a study varied by Latino subgroup, immigration age, gender, and age. Analysis highlighted that Mexican/Mexican Americans (76 %) and Central/South Americans (74 %) indicated a willingness to participate in research but also were less likely to have been “Asked” to participate in research (9 % and 6 % respectively) compared to the other subgroups (p < .05).

Conclusions

Insights from this study will inform the development of culturally tailored interventions aimed at successfully recruiting and retaining Latino populations in public health and clinical trials research, thereby contributing to more equitable and representative health outcomes.

查看原文本刊更多论文

弥合差距：了解拉丁美洲人参与不同亚群的公共卫生和临床试验研究的意愿

在公共卫生和临床试验研究中，种族和少数民族人口的代表性不足仍然是一个持续存在的问题。然而，尽管研究拉丁裔参与研究的文献越来越多，但研究拉丁裔亚群体之间差异的研究仍然有限。本研究的目的是调查在美国出生的拉丁美洲人和移民拉丁美洲人在参与研究方面的知识、意识和意愿有何不同。方法我们对拉丁裔成年人进行了以人口为基础的家庭电话调查（N = 1264），其中68%为墨西哥/墨西哥裔美国人，11%为中/南美人，8%为波多黎各人，其余13%自认为是“其他”。“建立信任调查”包括有效的标准化工具，旨在评估研究知识，人类受试者的保护，先前参与研究，移民身份（出生），在美国的时间长短和原籍国。结果研究发现，在青少年或青年时期移民到美国的拉美裔人比在美国出生的拉美裔人更愿意参与医学研究。在一项研究中，拉丁裔亚群体、移民年龄、性别和年龄对“服用”某些东西的意愿有所不同。分析强调，与其他亚组相比，墨西哥/墨西哥裔美国人（76%）和中美洲/南美洲人（74%）表示愿意参与研究，但被“要求”参与研究的可能性较小（分别为9%和6%）(p <；. 05)。本研究的结论将为制定适合文化的干预措施提供信息，旨在成功地在公共卫生和临床试验研究中招募和留住拉丁裔人口，从而促进更公平和更具代表性的健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Contemporary Clinical Trials Communications Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

2.70

自引率

6.70%

发文量

146

审稿时长

20 weeks

期刊介绍： Contemporary Clinical Trials Communications is an international peer reviewed open access journal that publishes articles pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from a wide range of disciplines including medicine, life science, pharmaceutical science, biostatistics, epidemiology, computer science, management science, behavioral science, and bioethics. Contemporary Clinical Trials Communications is unique in that it is outside the confines of disease specifications, and it strives to increase the transparency of medical research and reduce publication bias by publishing scientifically valid original research findings irrespective of their perceived importance, significance or impact. Both randomized and non-randomized trials are within the scope of the Journal. Some common topics include trial design rationale and methods, operational methodologies and challenges, and positive and negative trial results. In addition to original research, the Journal also welcomes other types of communications including, but are not limited to, methodology reviews, perspectives and discussions. Through timely dissemination of advances in clinical trials, the goal of Contemporary Clinical Trials Communications is to serve as a platform to enhance the communication and collaboration within the global clinical trials community that ultimately advances this field of research for the benefit of patients.