Oligoclonal Band Count as an Indicator of first onset presentation and Severity of Disability in Multiple Sclerosis Patients

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-02-13 DOI:10.1016/j.msard.2025.106336

Eman M Khedr , Bastawy Al-Fawal , Rana Gamal , Mostafa Saber , Ahmed Shoeb

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引用次数: 0

Abstract

Introduction

The predictive significance of cerebrospinal fluid oligoclonal band (OCB) counts in multiple sclerosis (MS) has been understudied. This study aims to evaluate the relationship between OCB counts and demographic measures, clinical rating scales, first onset presentation, and lesion localization.

Methods

Demographic, clinical, and radiological data were analyzed for 200 MS patients. The Expanded Disability Status Scale (EDSS), 25-Foot Walk Test (25-FWT), Symbol Digit Modalities Test (SDMT), and Multiple Sclerosis Impact Scale (MSIS) were also assessed. All data were correlated with OCB count with correction for multiple comparisons using the Bonferroni method.

Results

The mean number of OCBs in the studied cohort was 4.30±2.45. After Bonferroni correction, significant correlations were found between OCB counts and EDSS scores (p = 0.032), the presence of sensory symptoms at onset (p = 0.024), and a negative correlation with optic symptoms at onset (p = 0.016). No significant associations were observed between OCB counts and performance on other motor tests (the 9-HPT, and 25-FWT), SDMT, or MS phenotypes.

Conclusion

Higher OCB counts may indicate worse disease severity and sensory system affection as the first clinical presentation. Measuring OCB numbers is critical not only for MS diagnosis but to provide quantification of disease severity and guide proper treatment plans.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.