Plasma brain-derived neurotrophic factor before hemodialysis reduces the risk of depression in patients with chronic renal failure.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI:10.1080/0886022X.2025.2463561

Juan Antonio Suárez-Cuenca, Nuri Perla Campos-Nolasco, Ernesto Rodríguez-Ayala, Ana Daniela Zepeda-Làmbarry, Marta Georgina Ochoa-Madrigal, Diana Maldonado-Tapia, Eduardo Vera-Gómez, Alejandro Hernández-Patricio, Gustavo Martínez-Torres, Yareni Bernal-Figueroa, Juan Antonio Pineda-Juárez, José Gutiérrez-Salinas, Christian Gabriel Toledo-Lozano, Silvia García

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引用次数: 0

Abstract

Background: Neurotrophins are related with depressive disorders. Significant neurotrophins variations occur during renal replacement therapy, but whether peri-hemodialysis availability is associated with depression in patients with Chronic Kidney Disease (CKD) is yet unclear.

Aim: To determine dynamic concentrations of neurotrophins in the peri-hemodialysis range and their association with depressive symptoms in patients with CKD.

Methods: Pre-, and post-hemodialysis plasma concentrations of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), as well as their plasma clearance rates, were determined (multiplexing) in patients with stage 5 CKD. Depressive symptoms, as assessed by the Beck Depression Inventory-II (BDI-II), were determined. Finally, the bioavailability of BDNF and NGF was related to the score of depressive symptoms.

Results: Fifty-three patients were divided according to depressive symptoms. Pre-hemodialysis plasma BDNF was lower in patients with depressive disorder; whereas basal BDNF value >220 pg/mL independently reduced the risk for depressive disorder (Odds Ratio 0.23, p = 0.047) at uni- and multivariate analysis. Post-hemodialysis concentration and clearance rate of neurotrophins were not related with depressive symptoms.

Conclusion: Higher plasma BDNF before hemodialysis reduces the risk of mild depression in patients with CKD under renal replacement therapy.

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血液透析前血浆脑源性神经营养因子降低慢性肾衰竭患者抑郁的风险。

背景：神经营养因子与抑郁症有关。在肾脏替代治疗期间会发生显著的神经营养因子变化，但慢性肾脏疾病（CKD）患者的围血液透析可用性是否与抑郁相关尚不清楚。目的：探讨慢性肾病患者血液透析期神经营养因子动态浓度及其与抑郁症状的关系。方法：测定5期CKD患者血液透析前后脑源性神经营养因子（BDNF）和神经生长因子（NGF）血浆浓度及其血浆清除率（多路复用）。通过贝克抑郁量表- ii （BDI-II）评估抑郁症状。最后，BDNF和NGF的生物利用度与抑郁症状评分相关。结果：53例患者按抑郁症状进行分组。抑郁症患者血液透析前血浆BDNF较低；而在单因素和多因素分析中，基础BDNF值>220 pg/mL独立降低抑郁症的风险（优势比0.23,p = 0.047）。血液透析后神经营养因子浓度和清除率与抑郁症状无相关性。结论：血液透析前较高的血浆BDNF可降低接受肾脏替代治疗的CKD患者轻度抑郁的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.