Oral selenium supplementation improves the reproductive performance of rams: A systematic review and meta-analysis

IF 1.6 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Small Ruminant Research Pub Date : 2025-02-13 DOI:10.1016/j.smallrumres.2025.107465

Alfonso Longinos Muñoz-Benitez , Rodolfo Vieyra-Alberto , Juan Hebert Hernandez-Medrano , José Luis Ponce Covarrubias , Erika Georgina Hernández-Rojas , David Alejandro Contreras Caro del Castillo , Juan Carlos Angeles-Hernandez

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引用次数: 0

Abstract

Selenium (Se) plays a key role in maintaining integrity of the sperm membrane and modulating quality of ejaculate. A systematic search was conducted based on the following PICO question: "What is the effectiveness of Se supplementation (I) compared to no supplementation (C) on semen quality, testicular circumference and testosterone production (O) in rams (P)". The search was carried out by four experts using the PRISMA framework to avoid bias in the scientific database: PubMed, Google Scholar and Web of Science. The response variables were semen volume (SV), sperm cell concentration (SC), sperm progressive motility (SM), abnormal sperm % (AS), scrotal circumference (Scir), semen pH, serum Se concentration (SSe) and blood testosterone (BT). The effect size was estimated through the standardized (SMD) and raw mean difference (RMD). Heterogeneity was quantified using the I² index. The sources of heterogeneity were explored through a meta-regression including the covariates: breed, Se source (organic/inorganic), dosage, latitude, geographical zone, and semen collection technique (artificial vagina/electroejaculator). Oral supplementation of Se depicted a positive effect compared with not supplemented rams to SV (+0.15 ml), SM (+4.74 %), SC (+0.22 %), AS (-1.17 %), Scir (+0.86 cm), SSe (+3.98 µg/ml), and ST (+0.47 ng/ml). SM, AS, SC, and ST outcomes showed a better response to inorganic Se supplementation. There was a positive relationship between latitude and response to Se supplementation in SM and BT. In studies using the electroejaculation technique, the response to Se supplementation in SM and AS was significantly lower (P < 0.05). In addition, the percentage of abnormal sperm was increased with electroejaculation. In conclusion, oral Se supplementation improves semen quality in rams, which could have a positive effect on flock fertility. However, variables such as Se source, dosage and latitude should be considered when supplementing Se orally.

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硒（Se）在保持精子膜完整性和调节射精质量方面发挥着关键作用。我们根据以下 PICO 问题进行了系统检索："补充 Se（I）与不补充 Se（C）相比，对公羊（P）的精液质量、睾丸周长和睾酮分泌（O）有什么效果"。四位专家采用 PRISMA 框架进行了检索，以避免科学数据库出现偏差：PubMed、Google Scholar 和 Web of Science。响应变量包括精液量（SV）、精子细胞浓度（SC）、精子活动力（SM）、畸形精子百分比（AS）、阴囊周长（Scir）、精液 pH 值、血清 Se 浓度（SSe）和血液睾酮（BT）。效应大小通过标准化（SMD）和原始平均差（RMD）估算。异质性采用 I2 指数进行量化。通过元回归探讨了异质性的来源，元回归包括协变量：品种、Se 来源（有机/无机）、剂量、纬度、地理区域和精液采集技术（人工阴道/电子射精器）。与未补充 Se 的公羊相比，口服补充 Se 对 SV（+0.15 毫升）、SM（+4.74 %）、SC（+0.22 %）、AS（-1.17 %）、Scir（+0.86 厘米）、SSe（+3.98 微克/毫升）和 ST（+0.47 纳克/毫升）有积极影响。SM、AS、SC和ST结果对无机硒补充剂的反应较好。在 SM 和 BT 中，纬度与对 Se 补充剂的反应呈正相关。在使用电射精技术进行的研究中，SM 和 AS 对 Se 补充剂的反应明显较低（P < 0.05）。此外，畸形精子的百分比在电击射精中也有所增加。总之，口服补 Se 可提高公羊的精液质量，这可能对羊群的繁殖力产生积极影响。然而，口服 Se 时应考虑 Se 来源、剂量和纬度等变量。

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来源期刊

Small Ruminant Research 农林科学-奶制品与动物科学

CiteScore

3.10

自引率

11.10%

发文量

210

审稿时长

12.5 weeks

期刊介绍： Small Ruminant Research publishes original, basic and applied research articles, technical notes, and review articles on research relating to goats, sheep, deer, the New World camelids llama, alpaca, vicuna and guanaco, and the Old World camels. Topics covered include nutrition, physiology, anatomy, genetics, microbiology, ethology, product technology, socio-economics, management, sustainability and environment, veterinary medicine and husbandry engineering.