Objectively Measured Physical Activity among People with and without HIV in Uganda: Associations with Cardiovascular Risk and Coronary Artery Disease.

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Global Heart Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI:10.5334/gh.1398

Chinonso C Opara, Christine Horvat Davey, Cissy Kityo, Ellen Brinza, Rashidah Nazzinda, Marcio Summer Bittencourt, Vitor Oliveira, Allison R Webel, Chris T Longenecker

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引用次数: 0

Abstract

Background: Africa has a disproportionate burden of HIV-related cardiovascular disease. We aimed to describe physical activity in people living with HIV (PLHIV) and people without HIV (PWOH) in Uganda and characterize its relationship with the presence of computed tomography angiography-detected (CCTA) coronary artery disease (CAD).

Methods: We performed a cross-sectional analysis of the Ugandan Study of HIV Effects on the Myocardium and Atherosclerosis using Computed Tomography (mUTIMA-CT) cohort. From 2017-2019, physical activity in PLHIV and PWOH was assessed by accelerometry over seven days. Participants additionally underwent CCTA. Univariable and multivariable modified Poisson regression was used to analyze the relationship between physical activity and CAD presence.

Results: 168 participants were analyzed. The median (IQR) age was 57 (53-58) years old and 64% were female. Males had more moderate-to-vigorous physical activity per week [68 minutes (12-144) vs. 15 minutes (0-50), P < 0.001] and less light physical activity [788 minutes (497-1,202) vs. [1,059 (730-1490), P = 0.001] compared to females, but there was no difference by HIV status. After adjusting for age, which accounted for 10% of the variation in steps taken, and sex, no significant associations were found between physical activity and coronary plaque.

Conclusion: Objectively measured physical activity was low compared to guideline recommendations, with males being somewhat more active than females and without significant differences by HIV status. Physical activity was not associated with the presence of CAD independently of age and sex.

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乌干达艾滋病毒感染者和非感染者中客观测量的身体活动：与心血管风险和冠状动脉疾病的关系

背景：非洲与艾滋病毒相关的心血管疾病负担过重。我们的目的是描述乌干达艾滋病毒感染者（PLHIV）和非艾滋病毒感染者（PWOH）的身体活动情况，并描述其与计算机断层血管造影检测（CCTA）冠状动脉疾病（CAD）存在的关系。方法：我们使用计算机断层扫描（mUTIMA-CT）队列对乌干达HIV对心肌和动脉粥样硬化影响的研究进行了横断面分析。从2017-2019年，通过加速度计评估PLHIV和PWOH患者在7天内的身体活动。参与者还接受了CCTA。采用单变量和多变量修正泊松回归分析体力活动与CAD存在的关系。结果：对168名参与者进行了分析。中位（IQR）年龄为57岁（53-58岁），女性占64%。与女性相比，男性每周有更多的中高强度体力活动[68分钟（12-144）对15分钟（0-50），P < 0.001]，较少的轻度体力活动[788分钟（497- 1202）对[1059 (730-1490),P = 0.001]，但艾滋病毒感染状况没有差异。在对年龄和性别进行调整后，体力活动和冠状动脉斑块之间没有发现显著的关联。年龄和性别占所走步数变化的10%。结论：与指南建议相比，客观测量的身体活动较低，男性比女性更活跃，并且HIV状态没有显着差异。体育活动与CAD的存在无关，与年龄和性别无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.