Jin Wang, Javier Cabrera, Davit Sargsyan, Kanaka Tatikola, Kwok-Leung Tsui
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引用次数: 0
Abstract
This paper introduces a methodology for processing continuous monitoring device data, such as data from a wearable digital device or continuous telemetered data, to estimate outcomes like systolic blood pressure or treatment effects. One of the challenges of analyzing this type of data is to find a suitable binning or scaling to compress the information for improving outcome predictions. Another challenge is to select and weight the features to be included in the computational model. The new methodology consists of a combination of feature selection and feature weighting incorporated into the LASSO and the elastic net methods, which addresses both issues simultaneously. The compression of continuous data into weighted discretized data is a prominent issue in the development of AI methodology that is applied to wearable DHT devices. The new methodology was applied to a Fitbit data set from a Hong Kong elderly center study.
期刊介绍:
The Journal of Biopharmaceutical Statistics, a rapid publication journal, discusses quality applications of statistics in biopharmaceutical research and development. Now publishing six times per year, it includes expositions of statistical methodology with immediate applicability to biopharmaceutical research in the form of full-length and short manuscripts, review articles, selected/invited conference papers, short articles, and letters to the editor. Addressing timely and provocative topics important to the biostatistical profession, the journal covers:
Drug, device, and biological research and development;
Drug screening and drug design;
Assessment of pharmacological activity;
Pharmaceutical formulation and scale-up;
Preclinical safety assessment;
Bioavailability, bioequivalence, and pharmacokinetics;
Phase, I, II, and III clinical development including complex innovative designs;
Premarket approval assessment of clinical safety;
Postmarketing surveillance;
Big data and artificial intelligence and applications.