Significance of inflammation-related markers and histopathological features in mitral valve regurgitation.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Elena Carmen Opriş, Horaţiu Suciu, Alexandra Iulia Puşcaş, Sânziana Flămând, Marius Mihai Harpa, Cosmin Ioan Opriş, Ioan Jung, Cristian Olimpiu Popa, Kimberly Allisya Stefanya Neeter, Simona Gurzu
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引用次数: 0

Abstract

The lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), C-reactive protein (CRP)-to-lymphocyte ratio (CLR) and fibrinogen-to-albumin ratio (FAR) are well-known indicators of the systemic inflammatory response (SIR). Less is known about the association of SIR with the echocardiographic parameters and the histopathological (HP) aspects of the mitral valve in patients who have undergone cardiac surgery to repair or replace the mitral valve. Information on serum parameters, transesophageal echocardiography findings, and HP results was obtained from 166 patients who had undergone cardiac surgery to address mitral valve regurgitation. Among these patients, 30 were diagnosed with mitral valve prolapse, with 15 cases showing mitral valve flail or chordae rupture. The possible association between SIR, echocardiographic aspects of mitral valve flail and the HP aspect was checked. Fibrosis, hyalinization and myxoid degeneration of the valve were scored under microscope. Hyalinization of the mitral valve had a significant positive association with LMR and PLR (p=0.041 and p=0.03, respectively) and with NLR (p=0.093). A higher fibrosis degree was present in the valves without flail compared with those with flail (p=0.000). The monocyte average values of the group without flail were statistically significantly higher than those in the flail group (p=0.029). An increase of one unit in the value of monocytes was found to decrease the chances of flail [odds ratio (OR) 0.017, p=0.068, significant at p<0.1 level]. SIR parameters can be used to appraise inflammation status in mitral valve disease and to establish the risk of chordae rupture/flail in the case of mitral valve prolapse.

炎症相关标志物及组织病理学特征在二尖瓣反流中的意义。
淋巴细胞与单核细胞比率(LMR)、中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比率(PLR)、血小板与中性粒细胞比率(PNR)、c反应蛋白(CRP)与淋巴细胞比率(CLR)和纤维蛋白原与白蛋白比率(FAR)是众所周知的系统性炎症反应(SIR)指标。在接受心脏手术修复或置换二尖瓣的患者中,SIR与超声心动图参数和组织病理学(HP)方面的关系尚不清楚。从166例接受心脏手术治疗二尖瓣反流的患者中获得了血清参数、经食管超声心动图结果和HP结果的信息。其中30例诊断为二尖瓣脱垂,15例表现为二尖瓣连枷或二尖瓣索断裂。检查了二尖瓣连枷的SIR、超声心动图方面和HP方面之间可能的联系。显微镜下观察瓣膜纤维化、透明化及粘液样变性。二尖瓣透明化与LMR和PLR(分别为p=0.041和p=0.03)和NLR (p=0.093)呈正相关。无连枷瓣膜的纤维化程度高于有连枷瓣膜(p=0.000)。未连枷组单核细胞平均值高于连枷组,差异有统计学意义(p=0.029)。单核细胞值每增加一个单位,连枷发生的几率就会降低[比值比(OR) 0.017, p=0.068, p < 0.05]
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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