Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-02-15 DOI:10.4239/wjd.v16.i2.98085

Fang Lv, Xiao-Ling Cai, Xiu-Ying Zhang, Xiang-Hai Zhou, Xue-Yao Han, Yu-Feng Li, Li-Nong Ji

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引用次数: 0

Abstract

Background: The association between body mass index (BMI) and bone mineral density (BMD) has shown inconsistent results, varying by sex and skeletal site. Despite normal or elevated bone mass, individuals with type 2 diabetes have an increased risk of hip and vertebral fractures.

Aim: To assess lumbar spine trabecular volumetric BMD (vBMD) across different BMI categories in individuals with and without diabetes.

Methods: This cross-sectional study included 966 men over 50 years old and 1001 postmenopausal women from the Pinggu Metabolic Disease Study. The vBMD of lumbar vertebrae 2 through 4 was measured using quantitative computed tomography. Total adipose tissue, subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and lumbar skeletal muscle area were also quantified.

Results: In men with obesity (P = 0.038) and overweight (P = 0.032), vBMD was significantly higher in the diabetes group compared to non-diabetic men. After adjusting for age and sex, no significant saturation effect between BMI and BMD was found in participants with diabetes or in women without diabetes. However, a BMI threshold of 22.33 kg/m² indicated a saturation point for vBMD in non-diabetic men. Independent predictors of vBMD in men included age (r = -0.387, P < 0.001), BMI (r = 0.130, P = 0.004), and VAT (r = -0.145, P = 0.001). For women, significant predictors were age (r = -0.594, P < 0.001), BMI (r = 0.157, P = 0.004), VAT (r = -0.112, P = 0.001), and SAT (r = -0.068, P = 0.035).

Conclusion: The relationship between BMI and trabecular vBMD differs in individuals with and without diabetes. Overweight and obese men with diabetes exhibit higher vBMD.

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糖尿病和非糖尿病患者体重指数与腰椎体积骨密度的关系。

背景：身体质量指数（BMI）和骨密度（BMD）之间的关系显示出不一致的结果，因性别和骨骼部位而异。尽管骨量正常或升高，2型糖尿病患者髋部和椎体骨折的风险增加。目的：评估患有和不患有糖尿病的个体不同BMI类别的腰椎小梁体积骨密度（vBMD）。方法：本横断面研究包括966名50岁以上男性和1001名绝经后妇女，来自平谷代谢病研究。采用定量计算机断层扫描测量2 ~ 4腰椎的vBMD。总脂肪组织、皮下脂肪组织（SAT）、内脏脂肪组织（VAT）和腰椎骨骼肌面积也被量化。结果：在肥胖（P = 0.038）和超重（P = 0.032）的男性中，糖尿病组的vBMD明显高于非糖尿病组。在调整了年龄和性别后，在糖尿病患者和非糖尿病女性中，BMI和BMD之间没有发现明显的饱和效应。然而，BMI阈值为22.33 kg/m²表明非糖尿病男性的vBMD达到饱和点。男性vBMD的独立预测因子包括年龄（r = -0.387, P < 0.001）、BMI （r = 0.130, P = 0.004）和VAT （r = -0.145, P = 0.001）。对于女性，重要的预测因子是年龄（r = -0.594, P < 0.001）、BMI （r = 0.157, P = 0.004）、VAT （r = -0.112, P = 0.001）和SAT （r = -0.068, P = 0.035）。结论：BMI与小梁vBMD的关系在糖尿病患者和非糖尿病患者中存在差异。超重和肥胖的男性糖尿病患者表现出更高的vBMD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.