Musculoskeletal Manifestations of Rare Lymphoproliferative Neoplasms: A Retrospective Case Report of Four Cases.

Meagan E Tibbo, Max C Baron, Alina Syros, Jacob Cohen, H Thomas Temple, Brooke Crawford
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引用次数: 0

Abstract

Introduction: Lymphoproliferative neoplasms (LPNs) can lead to diverse musculoskeletal manifestations, presenting diagnostic challenges due to their rarity and atypical clinical features.

Case report: This retrospective case series, conducted at a tertiary care hospital, examines four patients with rare LPNs - Rosai-Dorfman disease, Kimura disease, and Castleman disease - initially misdiagnosed as nonneoplastic conditions. The study aims to underscore the importance of histopathological evaluation in achieving accurate diagnoses and initiating timely management. Results reveal diagnostic complexities, with an average of 2.5 biopsies required for accurate diagnosis.

Conclusions: In-depth case discussions highlight the unique challenges and treatment strategies for each LPN. The central theme emphasizes the critical role of histopathology in distinguishing these rare LPNs from more common musculoskeletal disorders, guiding appropriate therapeutic interventions, and optimizing patient outcomes. These cases serve as poignant examples of the diagnostic pitfalls encountered by clinicians when faced with rare LPNs, reinforcing the necessity of a nuanced approach and collaboration between clinicians and pathologists in achieving accurate diagnoses.

罕见淋巴增生性肿瘤的肌肉骨骼表现:附4例回顾性报告。
淋巴增生性肿瘤(lpn)可导致多种肌肉骨骼表现,由于其罕见和非典型临床特征,提出了诊断挑战。病例报告:本回顾性病例系列,在三级保健医院进行,检查了4例罕见的LPNs患者- Rosai-Dorfman病,Kimura病和Castleman病-最初被误诊为非肿瘤性疾病。该研究旨在强调组织病理学评估在实现准确诊断和及时管理中的重要性。结果显示诊断的复杂性,平均2.5活检需要准确的诊断。结论:深入的案例讨论突出了每个LPN的独特挑战和治疗策略。中心主题强调组织病理学在区分这些罕见的lpn与更常见的肌肉骨骼疾病,指导适当的治疗干预和优化患者预后方面的关键作用。这些病例是临床医生在面对罕见的lpn时遇到的诊断陷阱的尖锐例子,强调了临床医生和病理学家在实现准确诊断时采用细致入微的方法和合作的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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