Body height and risk of venous thromboembolism in men versus women.

IF 5.5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2025-02-14 DOI:10.1016/j.jtha.2025.02.006

Carl Arne Løchen Arnesen, Kristian Hveem, Maiken E Gabrielsen, John-Bjarne Hansen, Sigrid K Brækkan

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引用次数: 0

Abstract

Background: Body height is associated with venous thromboembolism (VTE) and may contribute to differences in VTE risk in men versus women.

Aims: To investigate the risk of VTE according to body height in men and women, and assess VTE risk in men versus women after adjustment for height in young, middle-aged, and elderly individuals.

Methods: Participants of the Tromsø Study (1994-2020) and the Nord-Trøndelag Health Study (1995-2019) formed the study cohort (n=114,567). Cox regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) of VTE per 10 cm increase in body height in men and women. VTE risk in men versus women was estimated in the age groups 19-49, 50-74 and ≥75 years before and after adjustment for height.

Results: Taller stature was associated with increased VTE risk in both men (HR: 1.34, CI: 1.25-1.44) and women (HR: 1.23, CI: 1.13-1.33). In the middle-aged, the risk was higher in men than in women (HR: 1.45, CI: 1.32-1.60), but diminished after adjustment for height (HR 0.98, CI 0.85-1.13). In the young (HR: 0.87, CI 0.70-1.08) and elderly (HR: 1.08, CI: 0.97-1.20) there was no difference in VTE risk in men versus women before adjustment, while the risk was higher in women after height adjustment (HR: 0.60, CI: 0.44-0.83 and HR: 0.83, CI: 0.71-0.97, respectively).

Conclusions: Taller stature was a risk factor for VTE in men and women. The risk of VTE in men versus women was substantially affected by adjustment for body height in all age groups.

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.