On-Pump FIBTEM-A5 Accurately Predicts the A5 Values After Protamine Administration.

IF 1.6 Q2 ANESTHESIOLOGY
Anesthesiology Research and Practice Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI:10.1155/anrp/2924468
Stanislaw Vander Zwaag, Matus Tomko, Tomas Madej, Jens Fassl
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Abstract

Introduction: In the present study, we aimed to investigate whether the measurements of the fibrinogen-dependent clot firmness in FIBTEM-one of the rotational thromboelastometry (ROTEM) assays-during cardiopulmonary bypass (CPB) accurately predict the values after protamine administration. Materials and Methods: In this single-center retrospective observational study, we analyzed a database of patients undergoing on-pump surgeries between May 2022 and February 2024. We included patients in whom an intraoperative ROTEM examination during CPB and a follow-up examination directly after protamine infusion were performed. We excluded patients who received either fibrinogen concentrate or fresh frozen plasma between the two examinations. FIBTEM A5 values in both examinations were compared. The Wilcoxon signed rank test was used to compare non-normally distributed data. Linear regression analysis was used to investigate the relationship between the on-pump and postprotamine FIBTEM A5 values. Results: Seventy patients were included in the statistical analysis. There was a slight but statistically significant difference between FIBTEM A5 during CPB (median 16.0 mm, IQR 10.0-22.0) and after protamine administration (median 15.5 mm, IQR 8.7-22.3, p = 0.021). However, in linear regression analysis, FIBTEM A5 values during the last 30 min of the extracorporeal circulation were a significant predictor of FIBTEM A5 after protamine administration (R = 0.902, R 2 = 0.813, adjusted R 2 = 0.810, F(df regression, df residual) = 295.980, p < 0.001). The equation: y = 0.911x+ 1 describes the line of best fit. Conclusions: Within the normal range limits, there is a very strong correlation between on-pump FIBTEM A5 values and FIBTEM A5 values after protamine administration.

泵上fitem -A5准确预测鱼精蛋白给药后A5值。
在本研究中,我们旨在研究体外循环(CPB)期间纤维蛋白原依赖性凝块硬度(fifitem)的测量-旋转血栓弹性测量(ROTEM)的一种-是否准确预测鱼精蛋白给药后的值。材料和方法:在这项单中心回顾性观察研究中,我们分析了2022年5月至2024年2月期间接受泵上手术的患者数据库。我们纳入了在CPB期间进行术中ROTEM检查和在鱼精蛋白输注后直接进行随访检查的患者。我们排除了在两次检查之间接受纤维蛋白原浓缩物或新鲜冷冻血浆的患者。比较两种检查的fitem A5值。采用Wilcoxon符号秩检验比较非正态分布数据。采用线性回归分析探讨泵上和鱼精蛋白后fitem A5值之间的关系。结果:70例患者纳入统计分析。CPB期间fitem A5(中位数16.0 mm, IQR 10.0-22.0)与鱼精蛋白治疗后fitem A5(中位数15.5 mm, IQR 8.7-22.3, p = 0.021)差异有统计学意义。然而,在线性回归分析中,体外循环最后30分钟的fitem A5值是鱼精蛋白给药后fitem A5的显著预测因子(R = 0.902, r2 = 0.813,调整后r2 = 0.810, F(df回归,df残差)= 295.980,p < 0.001)。方程y = 0.911x + 1描述了最佳拟合线。结论:在正常范围内,泵上fitem A5值与鱼精蛋白给药后fitem A5值有很强的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
29
审稿时长
18 weeks
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