Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models—A Randomized Clinical Trial

JAMA Pub Date : 2025-02-17 DOI:10.1001/jama.2024.28047
Ozan Unlu, Matthew Varugheese, Jiyeon Shin, Samantha M. Subramaniam, David Walter Jacques Stein, John J. St Laurent, Charlotte J. Mailly, Marian J. McPartlin, Fei Wang, Michael F. Oates, Christopher P. Cannon, Benjamin M. Scirica, Kavishwar B. Wagholikar, Samuel J. Aronson, Alexander J. Blood
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Abstract

This randomized clinical trial compares the efficiency of prescreening patients with heart failure using an artificial intelligence (AI) large language model for inclusion in a clinical trial vs manual prescreening.
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