Field-cycling imaging yields repeatable brain R₁ dispersion measurement at fields strengths below 0.2 Tesla with optimal fitting routine.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-02-15 DOI:10.1007/s10334-025-01230-w

Nicholas Senn, P James Ross, Reina Ayde, Vasiliki Mallikourti, Adarsh Krishna, Charly James, Clarisse F de Vries, Lionel M Broche, Gordon D Waiter, Mary Joan MacLeod

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引用次数: 0

Abstract

Objectives: By rapidly changing magnetic field strength between 0.2 and 200 mT during the pulse sequence Field-Cycling Imaging (FCI) makes it possible to identify and evaluate new quantitative markers of pathology derived from dispersion of spin-lattice relaxation rate (R₁) in vivo. The aim of this work was to determine the most effective approach to reliably estimate multi-field R₁ dispersion measurements in brain tissue using FCI.

Materials and methods: This repeatability study consisted of twenty participants with moderate or severe small vessel disease. Each participant underwent 3 T MRI and FCI scans, repeated 30 days apart. After R₁ maps were generated at 0.2, 2, 20, and 200 mT, co-registered tissue labels generated from 3 T MRI were used to extract tissue averaged values of R₁ dispersion from regions of white matter (WM) and WM hyperintensities (WMHs).

Results: The fitted model which yielded best overall image contrast between WM and WMH regions and R₁ dispersion model adherence was determined. Tissue averaged values of R₁ (0.2 mT) and R₁ dispersion slope exhibited Cohen's d effect sizes of 3.07 and 1.48, respectively, between regions of WM and WMH. The cohort study results were repeatable between study visits.

Discussion: Differences in R₁ measurements could repeatably be discerned between normal and abnormal appearing brain tissues.

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.