Field-cycling imaging yields repeatable brain R₁ dispersion measurement at fields strengths below 0.2 Tesla with optimal fitting routine.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-02-15 DOI:10.1007/s10334-025-01230-w

Nicholas Senn, P James Ross, Reina Ayde, Vasiliki Mallikourti, Adarsh Krishna, Charly James, Clarisse F de Vries, Lionel M Broche, Gordon D Waiter, Mary Joan MacLeod

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引用次数: 0

Abstract

Objectives: By rapidly changing magnetic field strength between 0.2 and 200 mT during the pulse sequence Field-Cycling Imaging (FCI) makes it possible to identify and evaluate new quantitative markers of pathology derived from dispersion of spin-lattice relaxation rate (R₁) in vivo. The aim of this work was to determine the most effective approach to reliably estimate multi-field R₁ dispersion measurements in brain tissue using FCI.

Materials and methods: This repeatability study consisted of twenty participants with moderate or severe small vessel disease. Each participant underwent 3 T MRI and FCI scans, repeated 30 days apart. After R₁ maps were generated at 0.2, 2, 20, and 200 mT, co-registered tissue labels generated from 3 T MRI were used to extract tissue averaged values of R₁ dispersion from regions of white matter (WM) and WM hyperintensities (WMHs).

Results: The fitted model which yielded best overall image contrast between WM and WMH regions and R₁ dispersion model adherence was determined. Tissue averaged values of R₁ (0.2 mT) and R₁ dispersion slope exhibited Cohen's d effect sizes of 3.07 and 1.48, respectively, between regions of WM and WMH. The cohort study results were repeatable between study visits.

Discussion: Differences in R₁ measurements could repeatably be discerned between normal and abnormal appearing brain tissues.

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磁场循环成像可在低于0.2特斯拉的磁场强度下获得可重复的脑R1色散测量，并具有最佳拟合程序。

目的：通过在脉冲序列中0.2 ~ 200mt之间快速变化的磁场强度，场循环成像（FCI）可以识别和评估体内自旋晶格弛豫速率（R1）分散的新的病理定量标记。这项工作的目的是确定最有效的方法来可靠地估计使用FCI在脑组织中的多场R1离散度测量。材料和方法：这项重复性研究包括20名患有中度或重度小血管疾病的参与者。每个参与者接受3次T MRI和FCI扫描，间隔30天重复。在0.2、2、20和200 mT生成R1图谱后，使用3t MRI生成的组织标记进行联合注册，从白质（WM）和WM高强度（wmh）区域提取组织R1离散度的平均值。结果：确定了WM和WMH区域整体图像对比度最佳的拟合模型和R1弥散模型依从性。在WM区和WMH区，R1 （0.2 mT）和R1弥散斜率的组织平均值分别表现出3.07和1.48的Cohen’s d效应。在两次研究访问之间，队列研究结果是可重复的。讨论：R1测量值的差异可以在正常和异常脑组织之间重复识别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.