A method to measure renal inner medullary perfusion using MR renography.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-02-15 DOI:10.1007/s10334-025-01225-7

A de Boer, K Sharma, B Alhummiany, S P Sourbron

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引用次数: 0

Abstract

Objective: In the kidney, the medulla is most susceptible to damage in case of hampered perfusion or oxygenation. Due to separate regulation of cortical and medullary perfusion, measurement of both is crucial to improve the understanding of renal pathophysiology. We aim to develop and evaluate a physiologically accurate model to measure renal inner medullary (F_med) and cortical perfusion (F_cor) separately.

Materials and methods: We developed a 7-compartment model of renal perfusion and used an iterated approach to fit 10 free parameters. Model stability and accuracy were tested on both patient data and simulations. Cortical perfusion and F_T (tubular flow or glomerular filtration rate per unit of tissue volume) were compared to a conventional 2-compartment filtration model.

Results: Average (standard deviation) F_med was 37(23)mL/100 mL/min. Fitting stability as expressed by the median (interquartile range) coefficient of variation between fits was 0.0(0.0-5.8)%, with outliers up to 81%. In simulations, F_med was underestimated by around 8%. Intra-class correlation coefficients for F_cor and F_T as measured with the 2- and 7- compartment model were 0.87 and 0.63, respectively.

Discussion: We developed a pharmacokinetic model closely following renal physiology. Although the results were vulnerable for overfitting, relatively stable results could be obtained even for F_med.

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磁共振肾造影测量肾髓内灌注的方法。

目的：在肾脏中，髓质在灌注或氧合受阻时最容易受到损伤。由于皮质和髓质灌注分别调节，测量两者对于提高对肾脏病理生理的理解至关重要。我们的目标是建立和评估一个生理上准确的模型来分别测量肾髓内灌注（Fmed）和皮质灌注（Fcor）。材料和方法：我们建立了一个7室肾灌注模型，并使用迭代方法拟合10个自由参数。模型的稳定性和准确性在患者数据和模拟上进行了测试。将皮质灌注和FT（单位组织体积的小管流量或肾小球滤过率）与传统的2室滤过模型进行比较。结果：平均（标准差）Fmed为37(23)mL/100 mL/min。拟合稳定性由拟合之间的中位数（四分位间距）变异系数表示为0.0(0.0-5.8)%，异常值高达81%。在模拟中，Fmed被低估了约8%。用2室和7室模型测量的for和FT的类内相关系数分别为0.87和0.63。讨论：我们建立了一个密切关注肾脏生理的药代动力学模型。虽然结果容易出现过拟合，但对于Fmed也能得到相对稳定的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.