Comparison of the effects of occlusal splint and Botox injections on the amount of mouth opening and chronic pain in individuals with temporomandibular disorders: a systematic review and meta-analysis.
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引用次数: 0
Abstract
Objective: This systematic review and meta-analysis study was carried out to compare the effectiveness of occlusal splint (OS) and Botox (BTX) injections in temporomandibular disorders (TMDs).
Material and methods: Irrespective of the starting year, studies were searched for up to 2024 using PubMed, Web of Science, Scopus databases and the Google Scholar search engine. In the study, graded chronic pain scale and maximum mouth opening amount parameters were analysed with Comprehensive Meta-Analysis programme.
Results: Out of 619 studies, only six were included in the meta-analysis. The effect size was 0.293 in favour of BTX in the studies evaluating the maximum mouth-opening (MMO) range. However, the amount of MMO did not show a statistically significant difference between the OS and BTX groups (95% CI - 0.383 to 0.969, P = 0.395, z = -0.850). In the subgroup analyses carried out based on the follow-up periods, it was found that the MMO was statistically significantly higher in the BTX group at the first week and in the OS group at the third month. However, there was no significant difference observed at the first, second, sixth and twelfth month follow-ups (P > 0.05). No significant difference was found between the groups (P > 0.05) in the publications that evaluated the graded chronic pain scale (GCPS), although an effect size of 0.673 was found in favour of OS (95% CI 0.331 to 1.365, P = 0.272, z = -1.098).
Conclusion: BTX injections and OS applications show significant differences in the MMO of individuals in the early period. In contrast, the MMO of individuals and the GCPS show similar findings in the sixth month and longer follow-up.
目的：本系统回顾和荟萃分析研究比较了咬合夹板（OS）和肉毒杆菌素（BTX）注射治疗颞下颌疾病（TMDs）的有效性。材料和方法：无论起始年份如何，研究都是通过PubMed， Web of Science， Scopus数据库和b谷歌Scholar搜索引擎搜索到2024年。采用综合meta分析程序对分级慢性疼痛量表和最大开口量参数进行分析。结果：619项研究中，只有6项纳入meta分析。在评价最大开口（MMO）范围的研究中，BTX的效应量为0.293。然而，MMO数量在OS组和BTX组之间无统计学差异（95% CI - 0.383 ~ 0.969, P = 0.395, z = -0.850）。在基于随访期进行的亚组分析中，发现BTX组在第一周和OS组在第三个月的MMO具有统计学意义上的显著性升高。但在第1、2、6、12个月随访时，两组间差异无统计学意义（P < 0.05）。在评估分级慢性疼痛量表（GCPS）的出版物中，两组之间没有发现显著差异（P > 0.05），尽管发现0.673的效应值有利于OS （95% CI 0.331至1.365,P = 0.272, z = -1.098）。结论：BTX注射和OS应用对个体早期MMO有显著差异。相比之下，个体的MMO和GCPS在6个月和更长时间的随访中显示出相似的结果。
期刊介绍：
The Australian Dental Journal provides a forum for the exchange of information about new and significant research in dentistry, promoting the discipline of dentistry in Australia and throughout the world. It comprises peer-reviewed research articles as its core material, supplemented by reviews, theoretical articles, special features and commentaries.
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