Tamara I Tamm, Valentyn V Nepomniashchyi, Sergey B Pavlov, Ivan M Mamontov, Olena A Shakalova, Olga B Litvinova
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Abstract
Objective: Aim: To study the histostructure of bone tissue in case of disruption of its blood supply and after restored blood flow in patients with ischemic form of diabetic foot syndrome..
Patients and methods: Materials and Methods: The histostructure of bone fragments in 25 patients with isolated ischemic form of diabetic foot syndrome was studied. Bone tissue biopsy specimens from 6 patients against the background of progressive ischemia were studied. In addition, the histostructure of bone tissue after revascularization with complete restoration of blood flow in 19 patients was studied.
Results: Results: The analysis of bone tissue biopsy specimens showed that disruption of blood supply of the limb tissues for a long time leads to impaired matrix calcification, decreased cortex thickness, widening of osteon channels and sparse trabecular network in the bone structure. Such changes were the signs of bone resorption that was not clinically or radiologically apparent. Revascularization with full restoration of blood flow promoted the appearance of signs of bone tissue regeneration in the form of vessel formation in bone and periosteum.
Conclusion: Conclusions: Adequate blood flow is an important clinical factor contributing to the restoration of bone regeneration in patients with ischemic form of diabetic foot syndrome.
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