Non-Hodgkin lymphoma in Williams syndrome: A coincidence or an association?

IF 2.5 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of the National Medical Association Pub Date : 2025-02-01 DOI:10.1016/j.jnma.2025.01.011

Merve Tanrısever Türk , Gizem Ürel Demir , Gülen Eda Utine , Bilgehan Yalçın , Pelin Özlem Şimşek-Kiper

引用次数: 0

Abstract

To date there have been multiple clinical reports of pediatric patients with Williams Beuren syndrome developing non-Hodgkin lymphoma. However, there is no clear evidence of an association between this microdeletion syndrome and lymphoma risk and as of yet there are no recommendations for cancer surveillance in the follow-up of these patients. In this report we descibe two patients with Williams Beuren syndrome, both of whom were diagnosed with non-Hodgkin lymphoma, one at the age of 2 years and the other at the age of 6 years during clinical follow-up. Although Williams-Beuren syndrome is not a cancer-predisposing genetic syndrome, rare cases of malignancy have been reported in these patients, necessitating consideration of this fact during patient follow-up.

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威廉斯综合征非霍奇金淋巴瘤：是巧合还是关联？

到目前为止，已经有多例威廉斯伯伦综合征患儿发展为非霍奇金淋巴瘤的临床报告。然而，没有明确的证据表明这种微缺失综合征与淋巴瘤风险之间存在关联，目前还没有建议在这些患者的随访中进行癌症监测。在这篇报告中，我们描述了两名患有Williams Beuren综合征的患者，他们都在临床随访中被诊断为非霍奇金淋巴瘤，一个在2岁，另一个在6岁。虽然Williams-Beuren综合征不是一种易患癌症的遗传综合征，但在这些患者中有罕见的恶性肿瘤病例报道，需要在患者随访时考虑这一事实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the National Medical Association 医学-医学：内科

CiteScore

4.80

自引率

3.00%

发文量

139

审稿时长

98 days

期刊介绍： Journal of the National Medical Association, the official journal of the National Medical Association, is a peer-reviewed publication whose purpose is to address medical care disparities of persons of African descent. The Journal of the National Medical Association is focused on specialized clinical research activities related to the health problems of African Americans and other minority groups. Special emphasis is placed on the application of medical science to improve the healthcare of underserved populations both in the United States and abroad. The Journal has the following objectives: (1) to expand the base of original peer-reviewed literature and the quality of that research on the topic of minority health; (2) to provide greater dissemination of this research; (3) to offer appropriate and timely recognition of the significant contributions of physicians who serve these populations; and (4) to promote engagement by member and non-member physicians in the overall goals and objectives of the National Medical Association.