Complex NADASE Infusions Improve Clinical Outcome in Substance Use Disorder: Descriptive Annotation in Fifty Cases.

Journal of addiction psychiatry Pub Date : 2024-08-23
Kenneth Blum, Thomas Mclaughlin, Kai Uwe Lewandrowski, Alireza Sharafshah, Catherine Dennen, Panayotis K Thanos, David Baron, Edward J Modestino, Keerthy Sunder, Kevin T Murphy, Milan Makle, Elizabeth Giley, Eric R Braverman, John Giordano, Rajendra D Badgaiyan
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Abstract

Background: The present study relates to a method to treat and detoxify patients with substance use disorder (SUD) utilizing a series of nicotinamide adenine dinucleotide (NAD+) and enkephalinase infusions (NADASE) in subjects attending chemical dependency programs.

Objective: The primary objective of the current investigation is to provide some additional clinical evidence to show that NAD+ other amino acids including d-phenylalanine, glycine and ananylglutamine dipeptide and Myer's cocktail (B complex) infusions significantly attenuates substance craving behavior and concomitant psychiatric burden sequalae in poly-drug abusers attending both in-patient and out-patient level of care in a number of chemical dependency programs in orange country.

Methods: At symmetry approximately 1,000 now performed approximately 1,000 infusions on 900 patients without any serious side effects pointing to the safety of this procedure. The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten. Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks. The data includes craving scores, anxiety, depression, and sleep. We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

Results: In summary considering all fifty subjects using wilcoxon signed rank tests and sign tests, we found the following significance comparing the baseline scores to post outcome scores after NAD infusions; craving scores (P = 1.063E-9); anxiety (P = 5.487E-7); and depression (P = 1.763E-4). There was an improvement trend in the number of sleep hours post infusions, it was non-significant (Pre 6.28, and post 7.34). Importantly, urine analysis of a standard panel of illicit drugs of abuse during the course of NAD infusions resulted in a subset of 40 patients tested at midway during infusions 100% of these patients tested negative.

Conclusion: These annotated notes serve an important function showing patient to patient similarities and differences and contribute to the emerging literature concerning NAD efficacy in SUD.

复合NADASE输注改善药物使用障碍的临床结果:50例描述性注释
背景:本研究涉及一种利用一系列烟酰胺腺嘌呤二核苷酸(NAD+)和脑啡肽酶(NADASE)输注治疗和解毒参加化学依赖项目的物质使用障碍(SUD)患者的方法。目的:本研究的主要目的是提供一些额外的临床证据,以证明NAD+其他氨基酸(包括d-苯丙氨酸、甘氨酸和氨酰谷氨酰胺二肽)和Myer鸡尾酒(B复合物)输注可显著减轻在橙色国家的一些化学依赖项目中住院和门诊水平护理的多重药物滥用者的物质渴望行为和伴随的精神负担后遗症。方法:在对称大约1000现在进行了大约1000次输注900名患者没有任何严重的副作用,指出这一过程的安全性。研究队列(n = 50)作为一个亚组,由高度成瘾的多种药物混合性别和不同种族的个体组成,这些个体先前对标准治疗有抗性,治疗失败的次数从1到10不等。本研究中的每位患者至少接受7次输注,平均持续时间为四周。这些数据包括渴望得分、焦虑、抑郁和睡眠。我们使用李克特量表(1 - 10)自我报告的回答,通过咨询师对患者进行结构化访谈来完成。结果:总的来说,考虑所有50名受试者使用wilcoxon符号秩检验和符号检验,我们发现NAD输注后基线评分与后结局评分比较具有以下显著性;渴望得分(P = 1.063E-9);焦虑(P = 5.487E-7);抑郁(P = 1.763E-4)。注射后睡眠时间有改善趋势,但无显著性差异(注射前为6.28,注射后为7.34)。重要的是,在NAD输注过程中对一个标准的非法药物滥用小组进行尿液分析,在输注过程中对40名患者进行了测试,其中100%的患者检测为阴性。结论:这些注释具有重要的功能,显示了患者之间的异同,并有助于新出现的关于NAD在SUD中的疗效的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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