Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Polycystic Ovary Syndrome in East Asia: A Review and Meta-Analysis.

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-02-11 DOI:10.1016/j.eprac.2025.01.011

Zhao Wu, Guining Liang, Ying Zhang, Renyuan Li

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Abstract

Objectives: The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing in women with polycystic ovary syndrome (PCOS). Epidemiologic literature regarding the risk factors for MASLD in PCOS women in East Asia is inconsistent. Studies of PCOS and MASLD in East Asia are restricted by limited data and various biases. Therefore, this meta-analysis was conducted.

Methods: This meta-analysis followed the MOOSE statement. Relevant studies published before July 13, 2023 were retrieved from the PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wan Fang, KISS, and Japan medical online databases. The related data were extracted, and the weighted mean difference, odds ratios and 95% confidence intervals were calculated.

Results: Twenty-four studies were included. Through univariate analysis, age, body mass index, waist-to-hip ratio (WHR), blood pressure, alanine transaminase, aspartate transaminase, fasting blood glucose, fasting insulin, homeostatic model assessment for insulin resistance (HOMA-IR), 2-hour postprandial blood glucose, 2 hour insulin, HBA1C, low-density lipoprotein cholesterol, triglyceride, total cholesterol, and testosterone were notably higher in PCOS women with MASLD, with high-density lipoprotein cholesterol markedly lower in PCOS women with MASLD. According to the pooled multivariate analysis, the WHR (P < .001), testosterone (P = .034), and HOMA-IR (P = .02) were substantially greater in PCOS women with MASLD.

Conclusion: MASLD is associated with obesity, IR, and hyperandrogenemia among PCOS women in East Asia. The abnormality of WHR, HOMA-IR, and testosterone suggested early screening of MASLD in this population.

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东亚多囊卵巢综合征患者代谢功能障碍相关脂肪变性肝病的危险因素：综述和荟萃分析

目的：代谢功能障碍相关脂肪变性肝病（MASLD）在多囊卵巢综合征（PCOS）女性中的发病率正在增加。流行病学文献关于东亚多囊卵巢综合征妇女MASLD的危险因素是不一致的。东亚地区PCOS和MASLD的研究受到数据有限和各种偏差的限制。因此，进行本荟萃分析。方法：本荟萃分析遵循MOOSE声明。检索PubMed、Embase、Cochrane Library、Web of Science、CNKI、VIP、万方、KISS、日本医学在线数据库中2023.7.13之前发表的相关研究。提取相关资料，计算加权平均差（WMD）、比值比（OR）和95%置信区间（95% ci）。结果：共纳入24项研究。单因素分析发现，年龄、体重指数（BMI）、腰臀比（WHR）、血压（BP）、谷丙转氨酶（ALT）、天冬氨酸转氨酶（AST）、空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素抵抗稳态模型评估（HOMA-IR）、餐后2 h血糖（2 h PBG）、2 h胰岛素、HBA1C、低密度脂蛋白胆固醇（LDL）、甘油三酯（TG）、总胆固醇（TC）和睾酮均显著高于PCOS合并MASLD女性。高密度脂蛋白胆固醇（HDL-c）在PCOS合并MASLD的女性中显著降低。结论：东亚多囊卵巢综合征（PCOS）女性的MASLD与肥胖、IR和高雄激素血症相关。WHR、HOMA-IR和睾酮异常提示该人群早期筛查MASLD。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.