Global, Regional, and National Epidemiology of Opioid Use Disorder Among Adolescents and Young Adults, 1990–2019

IF 5.5 2区医学 Q1 PEDIATRICS

Journal of Adolescent Health Pub Date : 2025-02-11 DOI:10.1016/j.jadohealth.2024.12.015

Fulei Han M.Med. , Bixuan Liu , Ligang Wang M.B.,B.S , Shuai Zhu , Xiaohui Li , Shan Kang Ph.D. , Xiao Niu , Jinlian Song Ph.D. , Yili Wu Ph.D.

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引用次数: 0

Abstract

Purpose

Opioid use disorder (OUD) is a growing public health crisis. However, no study to date has systematically evaluated the burden of OUD among adolescents and young adults (AYAs). We aimed to report the global level and trends of OUD burden among AYAs.

Methods

Data were obtained from the Global Burden of Disease study 2019, which was conducted from 1990 to 2019 in 204 countries. AYAs were defined as individuals aged 15–39 years, and the study period was 1990–2019. The burden of OUD was evaluated in terms of case numbers and age-standardized rates per 100,000 population.

Results

In 2019, there were 2,396,734 incident cases, 14,502,031 prevalent cases, 43,447 deaths, and 8,651,931 disability-adjusted life years of OUD among AYAs globally. High-income North America had the greatest regional burden, with the United States having the highest burden nationally. From 1990 to 2019, age-standardized incidence rate (ASIR), age-standardized prevalence rate, age-standardized mortality rate, and age-standardized disability-adjusted life years rate (ASDR) showed upward trends, with average annual percentage change of 0.62, 0.81, 1.55, and 1.01, respectively. Despite the burden of OUD was higher in males than in females, the increment in ASIR was greater in females than in males after 2014. Nationally, OUD burden showed increasing trends in ASIR, age-standardized prevalence rate, and ASDR across 150+ countries, with the United States experiencing the greatest increase in age-standardized mortality rate and ASDR. Meanwhile, there was a positive correlation between sociodemographic index and OUD burden, with higher sociodemographic index associated with a higher burden of OUD in 2019.

Discussion

OUD in AYAs is a major global public health issue, and the burden of OUD is increasing. This alarming trend underscores the urgent need for comprehensive prevention strategies, targeted interventions, and effective treatment options tailored to younger populations.

查看原文本刊更多论文

1990-2019年青少年和年轻人阿片类药物使用障碍的全球、区域和国家流行病学

目的：阿片类药物使用障碍（OUD）是一个日益严重的公共卫生危机。然而，迄今为止还没有研究系统地评估青少年和年轻人（AYAs）的OUD负担。我们的目的是报告AYAs中OUD负担的全球水平和趋势。方法：数据来自《2019年全球疾病负担研究》，该研究于1990年至2019年在204个国家进行。AYAs被定义为15-39岁的个体，研究期间为1990-2019年。根据病例数和每10万人的年龄标准化率来评估OUD的负担。结果：2019年，全球AYAs的OUD发病例数为2,396,734例，流行例数为14,502,031例，死亡例数为43,447例，残疾调整生命年为8,651,931年。高收入的北美地区的地区负担最重，而美国的全国负担最重。1990 - 2019年，年龄标准化发病率（ASIR）、年龄标准化患病率（患病率）、年龄标准化死亡率（死亡率）和年龄标准化伤残调整生命年率（ASDR）呈上升趋势，年均变化百分比分别为0.62、0.81、1.55和1.01。尽管男性的OUD负担高于女性，但2014年后女性的ASIR增量大于男性。在全国范围内，150多个国家的OUD负担在ASIR、年龄标准化患病率和ASDR方面呈上升趋势，其中美国的年龄标准化死亡率和ASDR增幅最大。同时，社会人口指数与OUD负担呈正相关，社会人口指数越高，2019年OUD负担越高。讨论：亚洲地区的OUD是一个重大的全球公共卫生问题，OUD的负担正在增加。这一令人震惊的趋势突出表明，迫切需要制定全面的预防战略、有针对性的干预措施和针对年轻人群的有效治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Adolescent Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

10.40

自引率

3.90%

发文量

526

审稿时长

46 days

期刊介绍： The Journal of Adolescent Health is a scientific publication dedicated to enhancing the health and well-being of adolescents and young adults. Our Journal covers a broad range of research topics, spanning from the basic biological and behavioral sciences to public health and policy. We welcome a variety of contributions, including original research papers, concise reports, literature reviews, clinical case reports, opinion pieces, and letters to the editor. We encourage professionals from diverse disciplines such as Anthropology, Education, Ethics, Global Health, Health Services Research, Law, Medicine, Mental and Behavioral Health, Nursing, Nutrition, Psychology, Public Health and Policy, Social Work, Sociology, and Youth Development to share their expertise and contribute to our mission of promoting adolescent health. Moreover, we value the voices of young individuals, family and community members, and healthcare professionals, and encourage them to submit poetry, personal narratives, images, and other creative works that provide unique insights into the experiences of adolescents and young adults. By combining scientific peer-reviewed research with creative expressions, our Journal aims to create a comprehensive understanding of the challenges and opportunities in adolescent and young adult health.