Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review

IF 5.5 2区医学 Q1 PEDIATRICS

Journal of Adolescent Health Pub Date : 2025-02-13 DOI:10.1016/j.jadohealth.2024.10.026

Jessica Duncan Cance Ph.D., M.P.H. , Sara Hairgrove M.P.H. , Lissette M. Saavedra Ph.D. , Erin E. Bonar Ph.D. , Maureen A. Walton Ph.D., M.P.H. , Sheila V. Patel Ph.D. , Amy M. Yule M.D. , Cheryl King Ph.D. , Laura J. Chavez Ph.D., M.P.H. , Natasha Slesnick Ph.D. , Claudia-Santi F. Fernandes Ed.D., L.P.C., M.C.H.E.S.

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引用次数: 0

Abstract

The purpose of this systematic review is to assess evidence for an association between opioid misuse and suicide-related outcomes among youth and young adults (aged 12–30 years). A Boolean search strategy of eligible publications from January 1990 to June 2024 identified 2,696 independent citations. An additional 10 were identified through reference screening. A total of 55 publications met the inclusion criteria. Twelve studies used administrative data and 43 were based on observational data. Risk of bias was assessed qualitatively by domain. Nearly all (98%) studies using observational data found an association between opioid misuse and at least one suicide-related outcome (e.g., suicidal ideation, suicide plan, suicide attempt). Administrative data studies had higher risk of bias compared with observational studies, typically due to higher confounding bias. Reporting bias was moderate to high across all studies in the review. Our review provides clear evidence of the association between opioid misuse and suicide-related outcomes among youth and young adults. However, we highlight a need for longitudinal research on the directionality of the association and potential mechanisms.

查看原文本刊更多论文

阿片类药物滥用和自杀相关的结果在青少年和年轻人：系统回顾。

本系统综述的目的是评估青少年和年轻人（12-30岁）阿片类药物滥用与自杀相关结果之间关联的证据。从1990年1月到2024年6月的合格出版物的布尔搜索策略确定了2,696个独立引用。通过参考筛选确定了另外10例。共有55篇出版物符合纳入标准。12项研究使用行政数据，43项研究基于观察数据。偏倚风险按领域进行定性评估。几乎所有（98%）使用观察性数据的研究都发现阿片类药物滥用与至少一种自杀相关结果（如自杀意念、自杀计划、自杀企图）之间存在关联。与观察性研究相比，行政数据研究具有更高的偏倚风险，这通常是由于较高的混杂偏倚。本综述中所有研究的报告偏倚均为中等至高偏倚。我们的综述提供了明确的证据，证明阿片类药物滥用与青少年和年轻人自杀相关结果之间存在关联。然而，我们强调需要对关联的方向性和潜在机制进行纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Adolescent Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

10.40

自引率

3.90%

发文量

526

审稿时长

46 days

期刊介绍： The Journal of Adolescent Health is a scientific publication dedicated to enhancing the health and well-being of adolescents and young adults. Our Journal covers a broad range of research topics, spanning from the basic biological and behavioral sciences to public health and policy. We welcome a variety of contributions, including original research papers, concise reports, literature reviews, clinical case reports, opinion pieces, and letters to the editor. We encourage professionals from diverse disciplines such as Anthropology, Education, Ethics, Global Health, Health Services Research, Law, Medicine, Mental and Behavioral Health, Nursing, Nutrition, Psychology, Public Health and Policy, Social Work, Sociology, and Youth Development to share their expertise and contribute to our mission of promoting adolescent health. Moreover, we value the voices of young individuals, family and community members, and healthcare professionals, and encourage them to submit poetry, personal narratives, images, and other creative works that provide unique insights into the experiences of adolescents and young adults. By combining scientific peer-reviewed research with creative expressions, our Journal aims to create a comprehensive understanding of the challenges and opportunities in adolescent and young adult health.