[Research progress on corneal endothelial disorders in individuals with diabetes].

Abstract

The corneal endothelium lines the innermost layer of the cornea. Normal pump and barrier function of corneal endothelial cells is crucial for the maintenance of corneal hydration, thickness and transparency. Numerous clinical studies have demonstrated that individuals with diabetes exhibit decreased endothelial cell counts, impaired pump and barrier functions and increased central corneal thickness when compared to non-diabetic individuals. And anterior segment surgery may exacerbate corneal endothelial injury. Protecting the corneal endothelium during surgery poses significant challenges to clinicians. This review provides an overview of the pathological mechanisms and potential treatments for the impairment of pump and barrier functions in diabetic corneal endothelial cell lesions, with the aim of identifying potential targets and therapies for diabetic corneal endothelial lesions.