Obtaining characterization and in vitro behavior of 3D multilayer ceramic scaffolds Ca2SiO4/Ca2P6O17/Ca2SiO4-XSr

IF 2.7 4区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Boletin de la Sociedad Espanola de Ceramica y Vidrio Pub Date : 2025-01-01 DOI:10.1016/j.bsecv.2024.12.001

Karina Salazar , Ángel Murciano , Pablo Velásquez , Piedad N. De Aza

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引用次数: 0

Abstract

In this study, 3D multilayer scaffolds were fabricated by sol–gel and polymeric replication methods. The principal objective was to fabricate scaffolds based on a core of Ca₂SiO4/Ca₂P₆O₁₇ (C₂S/P₆) to obtain mechanical resistance following by external layers with composition Ca₂SiO₄ (C₂S) doped with several amount of SrCO₃ (Sr = 0–2.5 wt%) to generate modulated bioactivity.

This scaffold was characterized from the physical, chemical and mineralogical point of view. Finally, the effect of the dopant on the surface morphology and how it affects the bioactivity was carried out according to the ISO 23317.2017 standard.

The obtained scaffolds exhibited an open porosity of 80–90% and a maximum mechanical strength of 1.2 ± 0.1 MPa. The scaffolds containing Sr²⁺ demonstrated bioactivity that could be modulated according to the Sr content. The results revealed that bioactivity occurred only when the scaffolds were coated with outer layers of strontium. Scaffolds doped with 1 and 1.5 wt% Sr displayed bioactivity after 3 days in simulated body fluid (SBF), while the 2.5 wt% Sr sample did not show bioactivity at any time.

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获得Ca2SiO4/Ca2P6O17/Ca2SiO4- xsr三维多层陶瓷支架的表征及体外行为

在本研究中，采用溶胶-凝胶和聚合复制的方法制备了三维多层支架。主要目的是制造基于Ca2SiO4/Ca2P6O17 （C2S/P6）核心的支架，以获得机械阻力，然后在外部层中掺杂一定量的SrCO3 （Sr = 0-2.5 wt%）的Ca2SiO4 (C2S)，以产生可调节的生物活性。从物理、化学和矿物学的角度对该支架进行了表征。最后，根据ISO 23317.2017标准进行掺杂剂对表面形貌的影响及其对生物活性的影响。所得支架的开孔率为80-90%，最大机械强度为1.2±0.1 MPa。含有Sr2+的支架显示出生物活性，并可根据Sr含量进行调节。结果表明，只有在支架外层包被锶时才会产生生物活性。掺入1 wt% Sr和1.5 wt% Sr的支架在模拟体液（SBF）中3天后显示出生物活性，而掺入2.5 wt% Sr的支架在任何时候都没有显示出生物活性。

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来源期刊

Boletin de la Sociedad Espanola de Ceramica y Vidrio 工程技术-材料科学：硅酸盐

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

103 days

期刊介绍： The Journal of the Spanish Ceramic and Glass Society publishes scientific articles and communications describing original research and reviews relating to ceramic materials and glasses. The main interests are on novel generic science and technology establishing the relationships between synthesis, processing microstructure and properties of materials. Papers may deal with ceramics and glasses included in any of the conventional categories: structural, functional, traditional, composites and cultural heritage. The main objective of the Journal of the Spanish Ceramic and Glass Society is to sustain a high standard research quality by means of appropriate reviewing procedures.