Nickel/Photo-Cocatalyzed Cross-Coupling of Enol Silyl Ethers with α-Trifluoromethyl Bromides to Access β-CF3-Substituted Ketones

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-03 DOI:10.1021/acs.orglett.4c0422010.1021/acs.orglett.4c04220

Yan Jiang, Youzhi Liao, Yi Zhao and Fei Pan*,

引用次数: 0

Abstract

Herein, we introduce a nickel-photocatalyzed cross-coupling reaction between enol silyl ethers and CF₃-substituted alkyl bromides. This method provides a streamlined approach for synthesizing a wide array of structurally diverse β-CF₃-substituted ketones, achieving favorable yields under mild conditions. The practicality of this methodology is further underscored by its successful application in the late-stage functionalization of various pharmaceuticals and natural products.

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镍/光共催化烯醇硅醚与α-三氟甲基溴交叉偶联制备β- cf3取代酮

本文介绍了镍光催化烯醇硅基醚与cf3取代的烷基溴间的交叉偶联反应。该方法为合成一系列结构多样的β- cf3取代酮提供了一种简化的方法，在温和的条件下获得了良好的产率。这种方法的实用性进一步强调了其在各种药物和天然产物的后期功能化的成功应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.