Regioselective Cu-Catalyzed Hydrosilylation of Internal Aryl Alkynes

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-30 DOI:10.1021/acs.orglett.4c0472210.1021/acs.orglett.4c04722

Samantha E. Sloane, Shashank P. Sancheti, Moataz S. Hendy, Kathryn M. Smith, Raviraj Ananda Thorat, Hathaithep Senkum and Joseph R. Clark*,

引用次数: 0

Abstract

Construction of vinylsilane building blocks is important for advancing the synthesis of complex small molecules and natural products. Herein, we report a highly regio- and stereoselective copper-catalyzed hydrosilylation of unsymmetrical internal aryl alkynes. The reaction is performed across a broad scope of internal aryl alkynes, providing exclusive access to α-vinylsilane alkenyl arene products, including several silylated small molecule drug analogs.

Abstract Image

查看原文本刊更多论文

区域选择性铜催化内芳基炔的硅氢化反应

乙烯基硅烷构建块的构建对于推进复杂小分子和天然产物的合成具有重要意义。在此，我们报道了一个高度区域选择性和立体选择性的铜催化不对称内芳基炔的硅氢化反应。该反应在广泛的内部芳基炔中进行，提供了α-乙烯基硅烷烯基芳烃产品的独家途径，包括几种硅基化的小分子药物类似物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.