Galangin Regulates Mucin 5AC Gene Expression via the Nuclear Factor-κB Inhibitor α/Nuclear Factor-κB p65 Pathway in Human Airway Epithelial Cells.

IF 3 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Biomolecules & Therapeutics Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI:10.4062/biomolther.2024.140
Rajib Hossain, Hyun Jae Lee, Choong Jae Lee
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引用次数: 0

Abstract

In this study, we investigated the effects of the flavonoid galangin on the expression of the mucin 5AC (MUC5AC) gene in airway cells. Human pulmonary epithelial NCI-H292 cells were pretreated with galangin for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. We also examined the effects of galangin on the PMA-induced nuclear factor-κB (NF-κB) signaling pathway. Galangin inhibited the production of glycoproteins and the expression of MUC5AC mRNA induced by PMA via prevention of NF-κB inhibitor α degradation and NF-κB p65 nuclear translocation. These findings indicated that galangin suppressed mucin gene expression by modulating the NF-κB signaling pathway in human pulmonary epithelial cells.

高良姜通过核因子-κB抑制剂α/核因子-κB p65通路调控人气道上皮细胞粘蛋白5AC基因表达
本研究探讨了类黄酮高良姜素对气道细胞MUC5AC基因表达的影响。我们用高良姜预处理人肺上皮细胞NCI-H292细胞30 min,然后用12-肉豆酸13-乙酸磷(PMA)刺激24 h。我们还研究了高良姜对PMA诱导的核因子-κB (NF-κB)信号通路的影响。高良姜通过抑制NF-κB抑制剂α降解和NF-κB p65核易位,抑制PMA诱导的糖蛋白生成和MUC5AC mRNA表达。上述结果提示高良姜通过调节肺上皮细胞NF-κB信号通路抑制粘蛋白基因表达。
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来源期刊
CiteScore
6.60
自引率
8.10%
发文量
72
审稿时长
6-12 weeks
期刊介绍: Biomolecules & Therapeutics (Biomolecules & Therapeutics) (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open access journal that covers pharmacological and toxicological fields related to bioactive molecules and therapeutics. It was launched in 1993 as "The Journal of Applied Pharmacology (ISSN 1225-6110)", and renamed "Biomolecules & Therapeutics" (Biomol Ther: abbreviated form) in 2008 (Volume 16, No. 1). It is published bimonthly in January, March, May, July, September and November. All manuscripts should be creative, informative, and contribute to the development of new drugs. Articles in the following categories are published: review articles and research articles.
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