Allergy Inhibition Using Naturally Occurring Compounds Targeting Thymic Stromal Lymphopoietin Pathways: a Comprehensive Review.

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Biomolecules & Therapeutics Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI:10.4062/biomolther.2024.177

Le Ba Vinh, Kyeong Seon Lee, Yoo Kyong Han, Young Jun Kim, Suzy Kim, Abdul Bari Shah, Youngjoo Byun, Ki Yong Lee

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引用次数: 0

Abstract

Naturally occurring compounds have widely been applied to treat diverse pharmacological effects, including asthma, allergic diseases, antioxidants, inflammation, antibiotics, and cancer. Recent research has revealed the essential role of the thymic stromal lymphopoietin (TSLP) in regulating inflammatory responses at mucosal barriers and maintaining immune homeostasis. Asthma, inflammation, and chronic obstructive pulmonary disease are allergic disorders in which TSLP plays a significant role. Although TSLP's role in type 2 immune responses has undergone comprehensive investigation, its involvement in inflammatory diseases and cancer has also been found to be expanding. However, investigating how to block the TSLP pathway using natural products has been limited. This paper summarizes the roles of various medicinal plants and their chemical components that effectively inhibit the TSLP pathway. In addition, we also highlight the contributions of several plant-derived compounds to treat allergic diseases via targeting TSLP. This review intends to offer innovative concepts to scientists investigating the use of naturally produced compounds and extracts for the treatment of allergic illnesses.

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针对胸腺基质淋巴生成素途径的天然化合物的过敏抑制：综合综述。

天然存在的化合物已广泛应用于治疗各种药理作用，包括哮喘、过敏性疾病、抗氧化剂、炎症、抗生素和癌症。最近的研究揭示了胸腺基质淋巴生成素（TSLP）在调节粘膜屏障的炎症反应和维持免疫稳态方面的重要作用。哮喘、炎症和慢性阻塞性肺疾病是过敏性疾病，TSLP在其中起重要作用。虽然TSLP在2型免疫应答中的作用已经得到了全面的研究，但它在炎症性疾病和癌症中的作用也被发现在扩大。然而，如何利用天然产物阻断TSLP通路的研究一直受到限制。本文综述了有效抑制TSLP通路的各种药用植物及其化学成分的作用。此外，我们还强调了几种植物源性化合物通过靶向TSLP治疗过敏性疾病的贡献。这篇综述旨在为科学家提供创新的概念，研究使用天然产生的化合物和提取物治疗过敏性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules & Therapeutics 医学-药学

CiteScore

6.60

自引率

8.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomolecules & Therapeutics (Biomolecules & Therapeutics) (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open access journal that covers pharmacological and toxicological fields related to bioactive molecules and therapeutics. It was launched in 1993 as "The Journal of Applied Pharmacology (ISSN 1225-6110)", and renamed "Biomolecules & Therapeutics" (Biomol Ther: abbreviated form) in 2008 (Volume 16, No. 1). It is published bimonthly in January, March, May, July, September and November. All manuscripts should be creative, informative, and contribute to the development of new drugs. Articles in the following categories are published: review articles and research articles.