B. R. Thorat, S. N. Mali, Umang Shah, A. Garg, R. Agrawal, S. A. Arvindekar, J. N. Cruz, M. Santana de Oliveira, A. B. Shaik, B. V. S. Lokesh
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引用次数: 0
Abstract
This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R1–HN–N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones’ role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.
期刊介绍：
Russian Journal of Bioorganic Chemistry publishes reviews and original experimental and theoretical studies on the structure, function, structure–activity relationships, and synthesis of biopolymers, such as proteins, nucleic acids, polysaccharides, mixed biopolymers, and their complexes, and low-molecular-weight biologically active compounds (peptides, sugars, lipids, antibiotics, etc.). The journal also covers selected aspects of neuro- and immunochemistry, biotechnology, and ecology.
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