Accessible Synthesis Methods and Physicochemical Properties of Quinoline-Derived Schiff Bases

IF 1.1 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
L. P. Hambardzumyan, I. L. Aleqsanyan
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引用次数: 0

Abstract

Objective: Quinoline derivatives have extensively been used for both pharmaceutical agents and as fluorescent dyes for bioimaging. However, typical synthesis of quinoline derivatives is generally through expensive methods at high temperatures. Methods: In the present study, an inexpensive and accessible method for the synthesis of Schiff bases based on 6-amino-4-hydroxy-2-methylquinoline was developed by condensing the amino group at the sixth position of quinoline with the aldehyde group of hydroxybenzaldehydes. Results and Discussion: Quinoline-based Schiff bases were found to exhibit significant intramolecular fluorescence with charge transfer with Stokes shifts. Conclusions: Studies of the physicochemical properties of the synthesized compounds have shown that the quinolinebased Schiff bases have luminescent properties of aggregation-induced emission (AIE). They emit short-wave blue-green light like many other water-soluble AIE luminogens.

Abstract Image

喹啉类席夫碱的合成方法及理化性质研究
目的:喹啉衍生物广泛用于药物制剂和生物成像荧光染料。然而,典型的喹啉衍生物的合成通常是通过昂贵的高温方法。方法:以6-氨基-4-羟基-2-甲基喹啉为基料,通过将喹啉第6位的氨基与羟基苯甲醛的醛基缩合,建立了一种廉价、易获得的合成希夫碱的方法。结果和讨论:发现喹啉基希夫碱表现出明显的分子内荧光,并伴有斯托克斯位移的电荷转移。结论:对合成化合物的理化性质研究表明,喹啉基希夫碱具有聚集诱导发光(AIE)的发光性质。它们像许多其他水溶性AIE发光物质一样发出短波蓝绿光。
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来源期刊
Russian Journal of Bioorganic Chemistry
Russian Journal of Bioorganic Chemistry 生物-生化与分子生物学
CiteScore
1.80
自引率
10.00%
发文量
118
审稿时长
3 months
期刊介绍: Russian Journal of Bioorganic Chemistry publishes reviews and original experimental and theoretical studies on the structure, function, structure–activity relationships, and synthesis of biopolymers, such as proteins, nucleic acids, polysaccharides, mixed biopolymers, and their complexes, and low-molecular-weight biologically active compounds (peptides, sugars, lipids, antibiotics, etc.). The journal also covers selected aspects of neuro- and immunochemistry, biotechnology, and ecology.
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