Efficacy of a parent-based treatment for children and adolescents with obsessive-compulsive disorder: Protocol of a multiple baseline, single-case experimental design study

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary Clinical Trials Communications Pub Date : 2025-02-11 DOI:10.1016/j.conctc.2025.101456

Julia D.K. Veeger , Luuk Stapersma , Eli R. Lebowitz , Bonne Zijlstra , Ramón Lindauer , Elisabeth M.W.J. Utens , Chaim Huijser

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引用次数: 0

Abstract

Background

Pediatric obsessive-compulsive disorder (OCD) is a severely impairing disorder, associated with high levels of family accommodation (FA). Approximately 40 % of youth do not benefit from first-line treatment options (cognitive behavioral therapy or pharmacotherapy). Supportive Parenting for Anxious Childhood Emotions (SPACE) is a parent-based treatment, teaching parents to reduce FA and increase supportive parenting, thereby aiming to improve the child's OCD. This article presents the protocol of a multiple baseline single-case experimental design (SCED) study to test the efficacy of SPACE in reducing OCD severity and FA in youth with OCD.

Methods

This SCED consists of a baseline, treatment, and follow-up phase. In total 25 youth (7–18 years) with OCD, who previously received cognitive behavioral therapy (CBT) unsuccessfully, aborted treatment early, or were not able to receive CBT due to too high levels of OCD/anxiety, and their parents will be included. They will be randomly allocated to one of three baseline phase options (4, 6 or 8 weeks). The treatment phase consists of 12 weekly sessions of SPACE with parents. Throughout all phases, OCD severity and FA will be briefly assessed thrice a week. Standard clinical measurements assessing OCD severity and FA and secondary parameters will be conducted at six timepoints, till 6 months follow-up.

Conclusion

Combining the innovative SPACE treatment with a SCED provides detailed insight into the relationship between OCD and FA over time. Studying this in clinical practice in complex cases that are normally understudied, helps to improve more personalized care for youth with OCD.

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以家长为基础的治疗对儿童和青少年强迫症的疗效：一项多基线、单例实验设计研究的方案

儿童强迫症（OCD）是一种严重的损害障碍，与高水平的家庭迁就（FA）有关。大约40%的年轻人没有从一线治疗方案（认知行为治疗或药物治疗）中获益。支持性育儿对儿童焦虑情绪（SPACE）是一种以父母为基础的治疗，教导父母减少FA，增加支持性育儿，从而旨在改善孩子的强迫症。本文介绍了一项多基线单病例实验设计（SCED）研究的方案，以测试SPACE在降低强迫症青少年的强迫症严重程度和FA方面的功效。方法本SCED包括基线、治疗和随访阶段。共有25名青少年（7-18岁）患有强迫症，他们之前接受认知行为治疗（CBT）失败，早期放弃治疗，或由于强迫症/焦虑水平过高而无法接受CBT，他们的父母将被包括在内。他们将被随机分配到三个基线阶段选择之一（4,6或8周）。治疗阶段包括每周与家长进行12次的SPACE会议。在所有阶段，强迫症的严重程度和FA将每周进行三次简短的评估。标准临床测量评估强迫症严重程度和FA和次要参数将在六个时间点进行，直到6个月的随访。将创新的SPACE治疗与SCED相结合，可以详细了解强迫症与FA之间的关系。在通常未被充分研究的复杂病例的临床实践中研究这一点，有助于为患有强迫症的青少年提供更加个性化的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contemporary Clinical Trials Communications Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

2.70

自引率

6.70%

发文量

146

审稿时长

20 weeks

期刊介绍： Contemporary Clinical Trials Communications is an international peer reviewed open access journal that publishes articles pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from a wide range of disciplines including medicine, life science, pharmaceutical science, biostatistics, epidemiology, computer science, management science, behavioral science, and bioethics. Contemporary Clinical Trials Communications is unique in that it is outside the confines of disease specifications, and it strives to increase the transparency of medical research and reduce publication bias by publishing scientifically valid original research findings irrespective of their perceived importance, significance or impact. Both randomized and non-randomized trials are within the scope of the Journal. Some common topics include trial design rationale and methods, operational methodologies and challenges, and positive and negative trial results. In addition to original research, the Journal also welcomes other types of communications including, but are not limited to, methodology reviews, perspectives and discussions. Through timely dissemination of advances in clinical trials, the goal of Contemporary Clinical Trials Communications is to serve as a platform to enhance the communication and collaboration within the global clinical trials community that ultimately advances this field of research for the benefit of patients.