Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory.

IF 2 Q3 ONCOLOGY
Anders E Berglund, John Puskas, Sean J Yoder, Andrew T Smith, Douglas C Marchion, Dahui Qin, James J Mulé, Javier F Torres-Roca, Steven A Eschrich
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Abstract

Significance: The RSI and 12CK GES are two GESs that predict tumor radiation sensitivity or the presence of tertiary lymphoid structures in tumors, respectively. These GESs were assessed within the CLIA process for future clinical use. We established proficiency, reproducibility, and reliability characteristics for both signatures in a controlled setting, indicating these GESs are suitable for validation within future clinical trials.

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