William C Reinhold, Elisabetta Marangoni, Fathi Elloumi, Remi Montagne, Sudhir Varma, Yanghsin Wang, Keyvan Rezai, Ludivine Morriset, Ahmed Dahmani, Rania El Botty, Léa Huguet, Makito Mizunuma, Naoko Takebe, Samuel Huguet, Augustin Luna, Yves Pommier
{"title":"Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study.","authors":"William C Reinhold, Elisabetta Marangoni, Fathi Elloumi, Remi Montagne, Sudhir Varma, Yanghsin Wang, Keyvan Rezai, Ludivine Morriset, Ahmed Dahmani, Rania El Botty, Léa Huguet, Makito Mizunuma, Naoko Takebe, Samuel Huguet, Augustin Luna, Yves Pommier","doi":"10.1158/2767-9764.CRC-24-0435","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>Acetalax and bisacodyl represent a prospective novel drug mechanism-of-action type, affect mitochondrial function and affect tumor growth in vivo. Their activity may be predicted by TRPM4 but with more accuracy adding other genes in multivariate analysis for triple negative breast cancer (TNBC). Acetalax has a biphasic mean half-life of 5.8 hours.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"375-388"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869203/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0435","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Significance: Acetalax and bisacodyl represent a prospective novel drug mechanism-of-action type, affect mitochondrial function and affect tumor growth in vivo. Their activity may be predicted by TRPM4 but with more accuracy adding other genes in multivariate analysis for triple negative breast cancer (TNBC). Acetalax has a biphasic mean half-life of 5.8 hours.