Urinary Estrogens in Girls Throughout Puberty as a Marker of Metabolic Risk and Their Relationship With Premature Adrenarche.

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Diego Zepeda, Ana Pereira, German Iñiguez, Veronica Mericq
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Abstract

Objective: The relationship between biochemical premature adrenarche (PA) in girls and metabolic alterations during puberty it is well described. A part of these circulating androgens undergoes aromatization in peripheral tissues to estrogens. This raises the question whether the metabolic effects are due to the action of androgens or estrogens. Our aim was to assess whether levels of urinary estrogens are associated with metabolic risk at late stages of puberty in girls with and without PA.

Methods: This prospective observational study included 321 girls from the Growth and Obesity Chilean Cohort Study (GOCS). Anthropometric and biochemical variables included in metabolic syndrome score (MetS) were measured along with urinary estrogens at Tanner stage B4, 1-year (M1) and 4-years after menarche (M4). Relationships between urinary estrogens and metabolic syndrome were analyzed during these periods. Furthermore, we analyzed whether metabolic disturbances in patients with biochemical PA (based on DHEA-S levels at age ~7) were mediated by androgens or estrogens.

Results: In multilevel analysis urinary estrone correlated positively with anthropometric variables (BMI, WC and fat percentage) and MetS score in adolescent girls. In contrast, urinary estradiol was not associated with metabolic risk. Interestingly, urinary estrogens were not associated with metabolic score in patients with biochemical PA.

Discussion: Our investigation suggests that metabolic risk in patients without biochemical PA are mostly associated with estrone levels. In contrast, in patients with biochemical PA, androgens are associated with MetS. Therefore, metabolic disturbances throughout puberty might be generated by different pathways in girls with and without biochemical PA.

女孩整个青春期的尿雌激素作为代谢风险的标志及其与过早性腺发育的关系。
目的:探讨女孩生化性肾上腺素过早(PA)与青春期代谢变化的关系。这些循环中的雄激素的一部分在外周组织中被芳构化为雌激素。这就提出了一个问题,代谢效应是由于雄激素还是雌激素的作用。我们的目的是评估尿雌激素水平是否与患有和不患有前列腺癌的女孩青春期晚期的代谢风险相关。方法:这项前瞻性观察研究纳入了来自智利生长与肥胖队列研究(GOCS)的321名女孩。在Tanner期B4、月经初潮后1年(M1)和4年(M4)测量代谢综合征评分(MetS)中包含的人体测量学和生化变量以及尿雌激素。分析这些时期尿雌激素与代谢综合征的关系。此外,我们分析了生化PA患者(基于7岁~7岁时DHEA-S水平)的代谢紊乱是由雄激素还是雌激素介导的。结果:在多水平分析中,尿雌酮与青春期女孩的人体测量变量(BMI、WC和脂肪百分比)和MetS评分呈正相关。相比之下,尿中雌二醇与代谢风险无关。有趣的是,尿雌激素与生化PA患者的代谢评分无关。讨论:我们的研究表明,无生化PA患者的代谢风险主要与雌酮水平相关。相反,在生化PA患者中,雄激素与MetS相关。因此,在有生化PA和没有生化PA的女孩中,整个青春期的代谢紊乱可能通过不同的途径产生。
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来源期刊
Clinical Endocrinology
Clinical Endocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
3.10%
发文量
192
审稿时长
1 months
期刊介绍: Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.
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