Yu. A. Sarmini, S. S. Sologubov, N. N. Smirnova, O. V. Stepanova, A.V. Markin
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引用次数: 0
Abstract
Precision adiabatic vacuum and high-precision differential scanning calorimetry (DSC) are used to study the temperature dependence of the heat capacity of betamethasone dipropionate in the range of 6–520 K for the first time. A phase transition of betamethasone dipropionate (melting) is detected in the above range of temperatures, and its thermodynamic characteristics are calculated. The low temperature heat capacity (20 ≤ T ≤ 50 K) is processed on the basis of a multifractal model, and the chain-layered topology of the structure is established. The thermal stability of the steroid hormone is studied via thermogravimetric analysis (TGA). It is found that the temperature at which the substance begins to decompose is 480 K. The experimental data are used to calculate standard thermodynamic functions in the region T → 0 to 480 K for the crystalline and liquid states of betamethasone dipropionate.
利用精密绝热真空和高精度差示扫描量热法（DSC）首次研究了二丙酸倍他米松热容量在 6-520 K 范围内的温度依赖性。在上述温度范围内检测到了倍他米松二丙酸酯的相变（熔化），并计算了其热力学特性。在多分形模型的基础上处理了低温热容量（20 ≤ T ≤ 50 K），并确定了结构的链层拓扑。通过热重分析（TGA）研究了类固醇激素的热稳定性。实验数据用于计算二丙酸倍他米松的结晶态和液态在 T → 0 至 480 K 区域的标准热力学函数。
期刊介绍：
Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world.
Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.
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