Supported silver nanoparticles over starch-modified magnetic nanoparticles: Characterization, Its application for A3 coupling reactions, analgesic and anesthetic activities

Abstract

This study focuses on the synthesis and characterization of silver nanoparticles (Ag NPs) supported on starch-coated magnetic Fe₃O₄ nanoparticles (Fe₃O₄-starch/Ag NPs) using a green approach, which avoids the use of any harmful or toxic reducing agents and stabilizers. The structural and textural properties of the nanocomposite were thoroughly examined using various physicochemical techniques, including TEM, FE-SEM, EDX, VSM, XRD and ICP-OES. The potential of Fe₃O₄-starch/Ag NPs as a catalyst in the aldehyde-alkyne-amine (A³) coupling reaction for the synthesis of propargylamine derivatives was also explored. This catalytic system offers significant benefits such as high catalytic efficiency, simplicity, environmental sustainability, and excellent reaction yields. The local anesthetic effects were assessed in models of frogs and guinea pigs, revealing noteworthy efficacy in both animal species. The analgesic effects were evaluated in mice by administering various doses orally. Writhing episodes caused by acetic acid were notably decreased in a manner that depended on the dosage. Furthermore, an assessment was conducted to determine the anti-inflammatory effects of the identical dosage. After being administered orally, the inflammation in the paws of mice induced by carrageenin, a commonly used inflammatory agent, was noticeably reduced. The Fe₃O₄-starch/Ag NPs nanocomposite shows promise as a groundbreaking therapeutic medication in the future, demonstrating analgesic, anti-inflammatory effects, and local anesthetic qualities.