Intracranial epidermoid cysts: Demographics, surgical strategies, and postoperative outcomes in a retrospective cohort study.

Abstract

Background: Intracranial epidermoid cysts are infrequent, benign, and slow-growing lesions derived from ectodermal vestiges. Although extremely uncommon, these lesions represent a great challenge from a diagnostic and surgical point of view because they are located close to major neurovascular structures with great potential for complications. Our work aims to analyze demographic, clinical, radiological, and surgical features in patients with intracranial epidermoid cysts and to assess post-surgical outcomes to define better management strategies.

Methods: We conducted a retrospective cohort study of patients diagnosed with histologically confirmed intracranial epidermoid cysts and treated surgically at Dr. Said Al-Witry's Neuroscience Hospital from January 2020 to September 2024. Demographic data, clinical presentations, imaging findings, surgical approaches, and postoperative complications were analyzed using descriptive statistics and Chi-square tests. Statistical significance was set at P < 0.05.

Results: Out of 40 patients, 75% were male, with headaches being the most common symptom (50%). Magnetic resonance imaging (MRI) findings demonstrated T1 hypo-intensity in 95% and T2 hyper-intensity in all cases. The retrosigmoid approach was the most frequently employed surgical method (60%), followed by frontotemporal (30%) and midline suboccipital (10%) approaches. Postoperative complications occurred in 35% of cases, including facial nerve palsy (15%), aseptic meningitis (10%), cerebrospinal fluid leaks (5%), and hydrocephalus (5%). Chi-square analysis showed significant associations between surgical approaches and postoperative complications (P = 0.048).

Conclusion: Intracranial epidermoid cysts show a high incidence in males and present mostly with nonspecific symptoms such as headaches and seizures. MRI remains the key investigation modality. The retrosigmoid approach shows less complication rate when compared to other techniques. Even though surgery has evolved, complications such as meningitis and nerve palsy persist, so much attention to detail is required in preoperative planning and follow-up in the long run for optimum outcomes for the patients.