GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE.

IF 0.6 4区医学 Q4 ORTHOPEDICS

Acta Ortopedica Brasileira Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI:10.1590/1413-785220253301e289573

William Bernardo Specht Rabuske, Michelle Ghert, Bruno Pereira Antunes, Carlos Roberto Galia, Julie Francine Cerutti Santos Pestilho, Gabriella Sityá Moojen da Silveira, Eduardo Areas Toller, Olavo Pires de Camargo, Edgard Eduard Engel, Suely Akiko Nakagawa, Alex Guedes, Ricardo Gehrke Becker

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Abstract

Objectives: To assess patient and tumor characteristics and treatment outcomes, focusing on local recurrence rates based on treatment type.

Methods: This is a retrospective review of cases of GCTB of the distal radius, identified from the databases of 74 patients in Brazilian institutions specializing in musculoskeletal tumor treatment. Data were collected from electronic and paper medical records by 18 centers between 1989 and 2021. Variables included demographic data, clinical presentation, treatment-related factors, and primary outcome (local recurrence rate).

Results: Among the 74 patients in the study, the mean age at diagnosis was 32.6 years, with a slight female predominance. Pathological fractures on presentation were observed in 15.7% of patients, and pulmonary metastasis in 1.4%. Treatment approaches were divided equally between intralesional curettage and en bloc resection. The overall local recurrence rate was 25.7% and was higher in patients treated with intralesional curettage (35.1%) compared to resection (16.2%).

Conclusions: The study confirms high recurrence risk with intralesional curettage, emphasizing the need for standardized protocols and improved surgical techniques to reduce recurrence rates and enhance outcomes for distal radius GCTB patients. Level of Evidence III; Retrospective Cohort Study.

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桡骨远端巨细胞瘤：局部复发的相关因素。

目的：评估患者和肿瘤的特征及治疗结果，重点关注基于治疗类型的局部复发率。方法：这是对桡骨远端GCTB病例的回顾性研究，从巴西专门从事肌肉骨骼肿瘤治疗机构的74例患者的数据库中确定。1989年至2021年间，18个中心从电子和纸质医疗记录中收集了数据。变量包括人口统计数据、临床表现、治疗相关因素和主要结局（局部复发率）。结果：74例患者中，平均诊断年龄为32.6岁，女性稍占优势。15.7%的患者出现病理性骨折，1.4%的患者出现肺转移。治疗方法平均分为病灶内刮除和整体切除。局部复发率为25.7%，病灶内刮除（35.1%）高于切除（16.2%）。结论：该研究证实了病灶内刮除的高复发风险，强调需要标准化的方案和改进的手术技术来降低桡骨远端GCTB患者的复发率并提高预后。证据等级III；回顾性队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.