Pancreatic surgery at the University Hospital Kralovske Vinohrady: 10-year review with a survival analysis for pancreatic ductal adenocarcinoma.

Q4 Medicine
R Gürlich, A Whitley, Z Šubrt, M Oliverius
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引用次数: 0

Abstract

Introduction: The aim of the study was to summarize the results of pancreatic surgery over a ten-year period at the surgical department of the university hospital Kralovske Vinohrady and analyse the prognostic factors of pancreatic ductal adenocarcinoma.

Methods: From October 2012 to December 2022, 331 patients underwent proximal pancreatectomy, 142 patients underwent distal pancreatectomy, and 84 patients underwent total pancreatectomy. Of the total number of resected patients, the analysis was performed only in patients with proven findings of ductal adenocarcinoma of the pancreas (221 patients). Survival analysis was conducted using the Kaplan-Meier method, and prognostic factors were assessed using Cox analysis for these patients.

Results: The average length of hospitalization was 13 days (3-53 days). According to the Clavien-Dindo classification, 90 patients had an uncomplicated postoperative course, 65 had minor complications (grade I and II), and 66 patients had major complications (grade III-V). Based on TNM staging, 27 patients were in stage I, 136 in stage II, 41 in stage III, and 17 in stage IV. The median survival was 304 days. Overall, 1-, 2-, 3-, and 5-year survival rates were 62.7% (95% confidence interval (CI) 55.9%-70.4%), 39.0% (95% CI: 31.9-47.6%), 27.3% (95% CI: 20.7-36.0%), and 12.8% (95% CI: 6.9%-24.0%), respectively. Using the Cox model, the following negative prognostic factors were identified: severe postoperative complications, positive lymph nodes, T stage, and positive resection margins.

Conclusion: Pancreatic ductal adenocarcinoma is an aggressive tumour. Radical resection represents the only chance for long-term survival. The best results are achieved in specialized centres with a high volume of pancreatic resections.

Kralovske Vinohrady大学医院胰腺外科:10年回顾和胰腺导管腺癌的生存分析。
简介:本研究的目的是总结Kralovske Vinohrady大学医院外科10年来胰腺手术的结果,并分析胰腺导管腺癌的预后因素。方法:2012年10月至2022年12月,行近端胰腺切除术331例,远端胰腺切除术142例,全胰切除术84例。在所有被切除的患者中,仅对证实为胰腺导管腺癌的患者(221例)进行了分析。采用Kaplan-Meier法进行生存分析,采用Cox分析评估预后因素。结果:平均住院时间13天(3 ~ 53天)。根据Clavien-Dindo分类,90例患者术后无并发症,65例有轻微并发症(I级和II级),66例有严重并发症(III-V级)。根据TNM分期,27例患者处于I期,136例处于II期,41例处于III期,17例处于IV期。中位生存期为304天。总体而言,1年、2年、3年和5年生存率分别为62.7%(95%可信区间(CI) 55.9%-70.4%)、39.0% (95% CI: 31.9-47.6%)、27.3% (95% CI: 20.7-36.0%)和12.8% (95% CI: 6.9%-24.0%)。采用Cox模型,确定了以下不良预后因素:严重的术后并发症、淋巴结阳性、T分期和切缘阳性。结论:胰腺导管腺癌是一种侵袭性肿瘤。根治性切除是长期生存的唯一机会。最好的结果是在专门的中心获得大量的胰腺切除术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Rozhledy v Chirurgii
Rozhledy v Chirurgii Medicine-Medicine (all)
CiteScore
0.50
自引率
0.00%
发文量
67
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