CuI–Zn(OAc)2 Catalyzed Selective CC Bond Cleavage of 1,3-Diketones/β-Ketoester for the Formation of Quinazolin-4(3H)-Ones: A Fast, Solvent-Free, Synthetic Strategy Under Microwave Irradiation

Abstract

CuI–Zn(OAc)₂ catalyzed a new, fast, solvent-free strategy for the synthesis of quinazolin-4(3H)-ones via selective scission of CC bond of the 1,3-diketone (both cyclic and acyclic) and β-ketoester was achieved under microwave irradiation. In contrast to the frequently applied synthetic strategy that involves cyclization-oxidation sequence of anthranilamides (2-aminobenzamides) with various aldehydes or benzyl alcohols, here, anthranilamide reacts with β-ketoester/1,3-diketo compounds in presence of CuI-Zn(OAc)₂ catalyst to form quinazolin-4(3H)-ones scaffold through an uncommon CC bond cleavage under solvent-free mild conditions with excellent yields. Besides, this method displays its capacity for gram-scale reactions.