Definition, Prognosis, and Complication Analysis of Early Allograft Dysfunction in Pediatric Liver Transplantation: A Retrospective Cohort Study

IF 2.4 2区医学 Q1 PEDIATRICS

Journal of pediatric surgery Pub Date : 2025-02-05 DOI:10.1016/j.jpedsurg.2025.162214

Zhuyuan Si , Zhixin Zhang , Shengqiao Zhao , Tianran Chen , Ruofan Wang , Guoyin Zou , Chong Dong , Kai Wang , Chao Sun , Weiping Zheng , Xinzhe Wei , Zhongyang Shen , Wei Gao

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引用次数: 0

Abstract

Background

The definition of early allograft dysfunction (EAD) varies, and has hardly been studied in pediatric transplantation (pLT) since the adult EAD definition is not easily applicable to pLT.

Methods

A retrospective analysis was conducted on consecutive pLT patients aged <18 at the Department of Pediatric Transplantation of Tianjin First Central Hospital from April 2013 to December 2022. The definition of EAD explored in this study is (1) international normalized ratio ≥2.8 on day 1 and aspartate aminotransferase >1500 IU/mL within the first 7 days or (2) total bilirubin ≥5 mg/dL on day 7. The overall survival of patients and graft survival at 90 days after surgery were compared between this new definition and the adult EAD definition.

Results

A total of 1620 pLT recipients were included in the study, of which 179 (11.0 %) recipients met the new definition of EAD for pLT. Twenty-five (13.97 %) died and 37 (20.67 %) graft lost within 90 days. The RR_death under Olthoff’s EAD definition and our EAD definition are 3.45 and 9.57, respectively; The RR_graft_loss under Olthoff’s EAD definition and our EAD definition are 4.18 and 11.48, respectively. A total of 97 (18.98 %) of 511 recipients who received deceased donor liver transplantation (DDLT) met the new definition of EAD, 18 (18.56 %) died and 29 (29.90 %) graft lost within 90 days. In DDLT group, the RR_death under Olthoff’s EAD definition and our EAD definition are 2.29 and 10.98, respectively; The RR_graft_loss under Olthoff’s EAD definition and our EAD definition are 2.34 and 11.24, respectively.

Conclusion

The broadly used Olthoff’s EAD definition in adult liver transplantation is unsuitable for pLT use. The EAD definition established in this study is more suitable for patients <18 years old who received pLT, especially those <18 years old who received DDLT.

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来源期刊

Journal of pediatric surgery 医学-外科

CiteScore

1.10

自引率

12.50%

发文量

569

审稿时长

38 days

期刊介绍： The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery. The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, pathology and surgical techniques, but also by attention to the unique emotional and physical needs of the young patient.