Local antibiotic delivery: Recent basic and translational science insights in orthopedics

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Bone Pub Date : 2025-02-04 DOI:10.1016/j.bone.2025.117416

Amir Human Hoveidaei , Seyedarad Mosalamiaghili , Amirhosein Sabaghian , Sina Hajiaghajani , Ali Soltani Farsani , Mahdi Sahebi , Mohammad Poursalehian , Basilia Onyinyechukwu Nwankwo , Janet D. Conway

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引用次数: 0

Abstract

Background

Infections remain a significant challenge in orthopedic settings despite advancements in preventive measures. Antibiotics are the primary defense against infections, but optimal delivery methods to the infection site are still being investigated. This review aims to examine existing approaches for local drug delivery from a basic science perspective.

Recent findings

Achieving adequate antibiotic concentration at the infection site is challenging due to compromised vasculature in ischemic conditions. Local administration methods, including antibiotic-loaded carriers such as impregnated bone grafts and various bone substitutes, are being explored as alternatives to systemic antibiotic use.

Summary

Various materials, including polymethyl methacrylate (PMMA), hydroxyapatite, calcium phosphate/sulfate, bone glass, and hydrogel, are being investigated for local antibiotic delivery. Some of these materials possess inherent antibacterial properties due to their chemical interactions. The selection of appropriate antibiotics, their dosage, release kinetics from the carrier material, physical behavior of the material/graft, and biocompatibility are key areas for further investigation in basic science research.

查看原文本刊更多论文

局部抗生素输送：骨科最新的基础和转化科学见解。

背景：尽管预防措施取得了进展，但感染仍然是骨科环境中的一个重大挑战。抗生素是预防感染的主要手段，但目前仍在研究将抗生素送到感染部位的最佳方法。本文旨在从基础科学的角度对现有的局部给药方法进行综述。最近的发现：由于缺血条件下血管系统受损，在感染部位达到足够的抗生素浓度是具有挑战性的。局部给药方法，包括抗生素负载载体，如浸渍骨移植物和各种骨替代品，正在探索作为全身抗生素使用的替代品。摘要：各种材料，包括聚甲基丙烯酸甲酯（PMMA）、羟基磷灰石、磷酸钙/硫酸钙、骨玻璃和水凝胶，正在研究用于局部抗生素递送的材料。其中一些材料由于其化学相互作用而具有固有的抗菌性能。合适抗生素的选择、用量、载体材料的释放动力学、材料/接枝的物理行为以及生物相容性是基础科学研究的重点领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bone 医学-内分泌学与代谢

CiteScore

8.90

自引率

4.90%

发文量

264

审稿时长

30 days

期刊介绍： BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.